ArticlePsychopharmacology2016
High H1-affinity antidepressants and risk of metabolic syndrome in bipolar disorder.
Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Risk of renal impairment in atypical antipsychotics: a systematic review and meta-analysis.European journal of clinical pharmacology · 2024Pooled it
- The risk of new-onset diabetes in antidepressant users - A systematic review and meta-analysis.PloS one · 2017Pooled it
- Triangulating the link between depression and liver disease: An integrative analysis of genetic, observational, and research trend data.Comprehensive psychoneuroendocrinology · 2026Article
- The interface of depression and diabetes: treatment considerations.Translational psychiatry · 2025Review
- Psychoactive substance consumption after the Fundão dam mine tailing disaster in Minas Gerais State, Brazil.Cadernos de saude publica · 2024Article
- The Effects of Use of Long-Term Second-Generation Antipsychotics on Liver and Kidney Function: A Prospective Study.Diseases (Basel, Switzerland) · 2022Article
- Time-Trends of Drug-Drug Interactions among Elderly Outpatients in the Piedmont Region (Italy): A Population-Based Study.International journal of environmental research and public health · 2022Article
- Potentially Inappropriate Prescribing among Elderly Outpatients: Evaluation of Temporal Trends 2012-2018 in Piedmont, Italy.International journal of environmental research and public health · 2022Article
- Depressive and Anxious Temperaments as Predictors of Late Onset Bipolar Disorder? Preliminary Results of a "Real World" Exploratory Study.Frontiers in psychiatry · 2022Article
- Use of State Sequence Analysis in Pharmacoepidemiology: A Tutorial.International journal of environmental research and public health · 2021Article
- Long Term Metabolic and Inflammatory Effects of Second-Generation Antipsychotics: A Study in Mentally Disordered Offenders.Journal of personalized medicine · 2021Article
- Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia.Journal of medicinal chemistry · 2021Article
- Lipid and Glycemic Profiles in Patients with Bipolar Disorder: Cholesterol Levels Are Reduced in Mania.Medicina (Kaunas, Lithuania) · 2020Article
- Cardiovascular risk in patients with severe mental illness in Italy.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Editorial: Brain-Metabolic Crossroads in Severe Mental Disorders-Focus on Metabolic Syndrome.Frontiers in psychiatry · 2019Article
- Detecting a potential safety signal of antidepressants and type 2 diabetes: a pharmacovigilance-pharmacodynamic study.British journal of clinical pharmacology · 2018Article
- The Impact of General Medical Conditions in Obsessive-Compulsive Disorder.Psychiatry investigation · 2018Article
- Increased Risk of Metabolic Syndrome in Antidepressants Users: A Mini Review.Frontiers in psychiatry · 2018Review
- Relationship of obstructive sleep apnea with major depressive disorder and development of metabolic syndrome.Indian journal of psychiatryArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleMetabolic syndrome (MetS) is common in patients with bipolar disorder, with a relative risk of 1.6-2 compared to the general population. The increased risk is believed to be due to unhealthy lifestyles and use of medications. Although antipsychotics and mood stabilizers have been associated with weight gain and MetS, the impact of antidepressants has not been comprehensively evaluated.
objectiveThe objective of the study is to assess the risk of MetS in patients exposed to different types of antidepressants.
methodsIn this cross-sectional study, 294 patients with bipolar disorder were consecutively recruited. MetS was diagnosed according to NCEP ATP-III modified criteria. Antidepressants used by the patients were classified according to the usual nomenclature (SSRI, TCA, SNRI, and other antidepressants) and a pharmacodynamic classification taking into account histamine 1-receptor (H1-R) affinity.
resultsUse of antidepressants in general was not associated with MetS (prevalence ratio [PR], 1.08; 95% confidence interval, 0.73 to 1.62; p = 0.70). However, subjects using H1-R high-affinity antidepressants (N = 15) showed a substantial increase in the prevalence of MetS (PR, 2.17; 95 % confidence interval, 1.24 to 3.80; p = 0.007). When we included the inhibition constant (Ki) as a continuous covariate in the models, we found an inverse association between Ki and prevalence of MetS (p = 0.004).
conclusionWe observed for the first time in a clinical setting that a pharmacodynamic-based classification of antidepressants could be more useful than the traditional one to predict the risk of MetS in patients with bipolar disorder. Clinical consequences may be relevant. However larger studies are warranted to generalize these results.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.