Trial reportTrials2015
Recruitment challenges in clinical research including cancer patients and their caregivers. A randomized controlled trial study and lessons learned.
Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Symptom Management for Cancer Patients and Their Caregivers Through Internet Support: A Randomized Clinical Trial
Evaluation of a Peer-led eHealth Wheelchair Skills Training Program: Training to Enhance Adaptation and Management for Wheelchair Users
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effectiveness of Pelvic Floor Muscle and Education-Based Therapies on Bladder, Bowel, Vaginal, Sexual, Psychological Function, Quality of Life, and Pelvic Floor Muscle Function in Females Treated for Gynecological Cancer: A Systematic Review.Current oncology reports · 2024Pooled it
- The application of crowdsourcing approaches to cancer research: a systematic review.Cancer medicine · 2017Pooled it
- Cancer survivorship monitoring systems for the collection of patient-reported outcomes: a systematic narrative review of international approaches.Journal of cancer survivorship : research and practice · 2017Pooled it
- RecoverEsupport-A Digital Health Intervention for Recovery After Breast Cancer Surgery: Feasibility and Acceptability Outcomes from a Pilot Randomized Controlled Trial.JMIR formative research · 2026Trial
- Fertility Preservation Discussions And Decisions: Results From a Pilot Randomized Controlled Trial Among Adolescent Males With Cancer.Pediatric blood & cancer · 2025Trial
- Non-invasive vagus nerve stimulation to reduce ileus after colorectal surgery: randomized feasibility trial and efficacy assessment (IDEAL Stage 2B).Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2024Trial
- Feasibility of a Multi-Component Strengths-Building Intervention for Caregivers of Persons With Heart Failure.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2023Trial
- The challenges of recruiting cancer patient/caregiver dyads: informing randomized controlled trials.BMC medical research methodology · 2018Trial
- Efficacy of a telephone outcall program to reduce caregiver burden among caregivers of cancer patients [PROTECT]: a randomised controlled trial.BMC cancer · 2018Trial
- Observational
- Participant recruitment and retention in randomised controlled trials of melanoma surveillance: A scoping review.Contemporary clinical trials communications · 2025Review
- Adaptation, Feasibility, and Acceptability of a Health Insurance Literacy Intervention for Caregivers of Pediatric Cancer Patients (CHAT-C).Current oncology (Toronto, Ont.) · 2025Article
- Partial AUCs in Long-Acting Injectables: Rationale, Challenges, Variability, Usefulness, and Clinical Relevance.Pharmaceutics · 2024Review
- Recruitment of informal caregivers into community oncology research studies: results from the 2022 Landscape Assessment.The oncologist · 2024Article
- Engaging athletes as research participants. A document analysis of published sport science literature.European journal of sport science · 2024Article
- Article
- Inequities in access to palliative and end-of-life care in the black population in Canada: a scoping review.International journal for equity in health · 2024Article
- Overcoming recruitment hurdles in clinical trials: An investigation of remote consenting modalities and their impact on workload, workflow, and usability.Applied ergonomics · 2024Article
- Physical Activity Together for Multiple Sclerosis (PAT-MS): A randomized controlled feasibility trial of a dyadic behaviour change intervention.Contemporary clinical trials communications · 2023Article
- Designing effective exercise intervention trials for prostate cancer cohorts: a qualitative study on experiences and views of exercise oncology researchers.BMC sports science, medicine & rehabilitation · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo test seven different strategies for recruitment in a randomized controlled trial, to report documented response data from each strategy, and to discuss recruitment challenges.
methodsWe used 5 opt-in (potential participants have to do something active to contact or be contacted by the researcher) and 2 opt-out (potential participants have the option to decline being contacted about a study) recruitment strategies from February 2013 until July 2014 to contact 1562 cancer patient candidates for participation in a randomized controlled trial. For each of these cancer patients a caregiver was also invited to take part in the study.
resultsOf the 1562 candidates, 22.6 % were ineligible on initial contact, 56.7 % declined to participate on initial contact, and 8.9 % agreed orally to participate but did not complete the enrollment. The 2 opt-out strategies, on-site recruitment and routine care letters recruitment, yielded the highest number of recruited participants with 79 dyads and 58 dyads respectively, constituting 42.7 % and 31.4 % of the total number of enrolled candidates. The 5 opt-in recruitment approaches yielded 49 dyads for the study. Almost half of these dyads were recruited using the approach termed "relying on providers at the hospital."
conclusionsIn this study, opt-out recruitment strategies appeared to be the most effective.
trial registrationRegistration number NCT01867723 , registered February 2012.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.