ArticleBirth defects research. Part A, Clinical and molecular teratology2016
Success rates for consent and collection of prenatal biological specimens in an epidemiologic survey of child health.
Article in Birth defects research. Part A, Clinical and molecular teratology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Article
- Associations between food frequency checklist responses and internal biomarkers of exposure to pesticides and heavy metals among U.S. pregnant women.Next research · 2025Article
- Assessing lead exposure in U.S. pregnant women using biological and residential measurements.The Science of the total environment · 2023Article
- Geographic and demographic variability in serum PFAS concentrations for pregnant women in the United States.Journal of exposure science & environmental epidemiology · 2023Article
- Feasibility of mail-based biospecimen collection in an online preconception cohort study.Frontiers in reproductive health · 2022Article
- The National Children's Study Archive Model: A 3-Tier Framework for Dissemination of Data and Specimens for General Use and Secondary Analysis.Frontiers in public health · 2021Article
- Willingness of women to participate in obstetrical and pediatric research involving biobanks.Journal of community genetics · 2020Article
- Assessment of Exposure to VOCs among Pregnant Women in the National Children's Study.International journal of environmental research and public health · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe National Children's Study (NCS) Vanguard Study began enrollment in January 2009 as an initial pilot study for a planned large-scale, longitudinal U.S. cohort study of the effect of environmental influences on child health and development, with biological and environmental sample collection conducted in seven locations from April 2009 to October 2010. We sought to determine rates of consent for, and success of collection of, maternal and paternal biospecimens before and during pregnancy in the NCS Vanguard Study.
methodsSamples of blood, saliva, vaginal swabs, urine, hair, and nails were collected before and during pregnancy. All specimens were sent to a central repository for processing, storage, and quality assessment.
resultsOf 780 pregnant women asked to consent to sample collection, 773 (>99%) agreed, and of 295 nonpregnant women, 292 (99%) agreed. Of 440 fathers asked to consent to sample collection, 435 (99%) agreed. Frequency of successful collection of biospecimens varied depending on sample and visit type. In descending order, the ranges over all visit types of the proportion of expected samples successfully collected from women were: urine, 92.5 to 95.7%; hair, 89.6 to 92.5%; vaginal swab, 84.2 to 88.5%; blood, 74.9 to 78.5%; 2-day saliva, 65.8 to 81.6%; and nails, 76.4 to 76.7%. For fathers, rates were highest for urine (94.9%) and lowest for hair (63.0%).
conclusionHigh rates of consent for and collection of a wide variety of biospecimens can be achieved in prospective epidemiologic cohort studies of pregnant women. Ease of sample collection may be a primary factor influencing successful biospecimen collection.
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