ArticleJournal of the American Academy of Child and Adolescent Psychiatry2015
A neural substrate for behavioral inhibition in the risk for major depressive disorder.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive Performance in First-Degree Relatives of Individuals With vs Without Major Depressive Disorder: A Meta-analysis.JAMA psychiatry · 2019Pooled it
- Executive Dysfunction and Depression Risk in Adolescence: Functional-MRI Analysis of Transient Network States During a Working Memory Task.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework.Psychiatry research. Neuroimaging · 2025Review
- Higher amplitudes of visual networks are associated with trait- but not state-depression.Psychological medicine · 2024Article
- The Importance of Low-frequency Alpha (8-10 Hz) Waves and Default Mode Network in Behavioral Inhibition.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Neural Circuit Markers of Familial Risk for Depression Among Healthy Youths in the Adolescent Brain Cognitive Development Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Bridging Anxiety and Depression: A Network Approach in Anxious Adolescents.Journal of affective disorders · 2021Article
- Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation.Translational psychiatry · 2019Article
- Limbic Intrinsic Connectivity in Depressed and High-Risk Youth.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- Perinatal maternal depressive symptoms alter amygdala functional connectivity in girls.Human brain mapping · 2018Article
- Article
- Decreased anticipated pleasure correlates with increased salience network resting state functional connectivity in adolescents with depressive symptomatology.Journal of psychiatric research · 2016Article
- Cortical-Subcortical Interactions in Depression: From Animal Models to Human Psychopathology.Frontiers in systems neuroscience · 2016Review
- Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset.NeuroImage. ClinicalArticle
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Authors and funding
9 authors.
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Abstract
objectiveBehavioral inhibition (BI) is an early developing trait associated with cautiousness and development of clinical depression and anxiety. Little is known about the neural basis of BI and its predictive importance concerning risk for internalizing disorders. We looked at functional connectivity of the default-mode network (DMN) and salience network (SN), given their respective roles in self-relational and threat processing, in the risk for internalizing disorders, with an emphasis on determining the functional significance of these networks for BI.
methodWe used functional magnetic resonance imaging to scan, during the resting state, children and adolescents 8 to 17 years of age who were either at high familial risk (HR; n = 16) or low familial risk (LR; n = 18) for developing clinical depression and/or anxiety. Whole-brain DMN and SN functional connectivity were estimated for each participant and compared across groups. We also compared the LR and HR groups on levels of BI and anxiety, and incorporated these data into follow-up neurobehavioral correlation analyses.
resultsThe HR group, relative to the LR group, showed significantly decreased DMN connectivity with the ventral striatum and bilateral sensorimotor cortices. Within the HR group, trait BI increased as DMN connectivity with the ventral striatum and sensorimotor cortex decreased. The HR and LR groups did not differ with respect to SN connectivity.
conclusionOur findings show, in the risk for internalizing disorders, a negative functional relation between brain regions supporting self-relational processes and reward prediction. These findings represent a potential neural substrate for behavioral inhibition in the risk for clinical depression and anxiety.
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