ArticlePloS one2015
Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- M phase-specific generation of supernumerary centrioles in cancer cells.Molecular biology of the cell · 2025Article
- APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells.EMBO reports · 2023Article
- Generation and Fates of Supernumerary Centrioles in Dividing Cells.Molecules and cells · 2021Review
- Triple deletion ofCell cycle (Georgetown, Tex.) · 2021Article
- Centriole-less pericentriolar material serves as a microtubule organizing center at the base of C. elegans sensory cilia.Current biology : CB · 2021Article
- Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle.The Journal of cell biology · 2021Article
- Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.The Journal of cell biology · 2021Article
- With Age Comes Maturity: Biochemical and Structural Transformation of a Human Centriole in the Making.Cells · 2020Review
- Dissecting the Genetic and Etiological Causes of Primary Microcephaly.Frontiers in neurology · 2020Review
- HDAC3 and HDAC8 are required for cilia assembly and elongation.Biology open · 2019Article
- The Cep57-pericentrin module organizes PCM expansion and centriole engagement.Nature communications · 2019Article
- Uncoordinated centrosome cycle underlies the instability of non-diploid somatic cells in mammals.The Journal of cell biology · 2018Article
- Caspase-mediated cleavage of the centrosomal proteins during apoptosis.Cell death & disease · 2018Article
- Building the right centriole for each cell type.The Journal of cell biology · 2018Review
- Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay.Nature communications · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A procentriole is assembled next to the mother centriole during S phase and remains associated until M phase. After functioning as a spindle pole during mitosis, the mother centriole and procentriole are separated at the end of mitosis. A close association of the centriole pair is regarded as an intrinsic block to the centriole reduplication. Therefore, deregulation of this process may cause a problem in the centriole number control, resulting in increased genomic instability. Despite its importance for faithful centriole duplication, the mechanism of centriole separation is not fully understood yet. Here, we report that centriole pairs are prematurely separated in cells whose cell cycle is arrested at M phase by STLC. Dispersal of the pericentriolar material (PCM) was accompanied. This phenomenon was independent of the separase activity but needed the PLK1 activity. Nocodazole effectively inhibited centriole scattering in STLC-treated cells, possibly by reducing the microtubule pulling force around centrosomes. Inhibition of PLK1 also reduced the premature separation of centrioles and the PCM dispersal as well. These results revealed the importance of PCM integrity in centriole association. Therefore, we propose that PCM disassembly is one of the driving forces for centriole separation during mitotic exit.
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