Evidence map›Paper›PMID 26407226›Full record

ArticlePsychosomatic medicine2015

Asthma-Related Immune Responses in Youth With Asthma: Associations With Maternal Responsiveness and Expressions of Positive and Negative Affect in Daily Life.

Erin T Tobin, Heidi S Kane, Daniel J Saleh, Derek E Wildman, Elizabeth Crabb Breen, Elizabeth Secord, Richard B Slatcher

Open access · greenAbstract read
In one paragraph

Article in Psychosomatic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Optimal sampling strategies for characterizing behavior and affect from ambulatory audio recordings.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2020
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  11. Automated Detection of Infant Holding Using Wearable Sensing: Implications for Developmental Science And Intervention.Proceedings of the ACM on interactive, mobile, wearable and ubiquitous technologies · 2019
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  12. Review
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  14. Article
  15. Article
  16. Objectively Measured Social Integration Is Associated With an Immune Risk Phenotype Following Marital Separation.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018
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  17. Article
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  20. Youth reports of parents' romantic relationship quality: Links to physical health.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Erin T TobinFrom the Department of Psychology (Tobin), Wayne State University, Detroit, Michigan; School of Behavioral and Brain Sciences (Kane), University of Texas at Dallas, Dallas, Texas; Department of Psychology (Saleh), Wayne State University, Detroit, Michigan; Department of Molecular and Integrative Physiology (Wildman), University of Illinois, Urbana, Illinois; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine (Breen), University of California, Los Angeles, Los Angeles, California; Allergy/Immunology Department (Secord), Children's Hospital of Michigan, Detroit, Michigan; and Department of Psychology (Slatcher), Wayne State University, Detroit, Michigan.
Heidi S Kane
Daniel J Saleh
Derek E Wildman
Elizabeth Crabb Breen
Elizabeth Secord
Richard B Slatcher
Wayne State University · US

Funding

Risky Family Environments and Childhood AsthmaR01HL114097 · NHLBI · WAYNE STATE UNIVERSITY · PI SLATCHER, RICHARD B, ZILIOLI, SAMUELE · 2011 to 2019
$5.6M
NHLBI NIH HHS R01 HL114097NHLBI NIH HHS R01HL114097
6 · The paper itself

Abstract

objectivesStressful family environments early in life have negative effects on physical health. However, less is known about the health effects of positive aspects of families. We examined the associations between maternal responsiveness and immune markers among youth with asthma and identified youth expressions of positive affect as a potential mechanism of these associations.

methodsForty-three youths with asthma (26 boys; aged 10-17 years) wore the Electronically Activated Recorder for 4 days to assess maternal responsiveness and youth expressions of affect from audio-recordings of daily life. Trained coders rated Electronically Activated Recorder sound files for expressions of maternal responsiveness and affect displayed by the youth. Peripheral blood mononuclear cells were isolated, cultured, and assayed to determine stimulated levels of interleukin (IL)-5, IL-13, and interferon-γ.

resultsGreater maternal responsiveness was associated with decreased stimulated production of IL-5 (r = -0.38, p = .012) and IL-13 (r = -0.33, p = .031). Greater total positive affect in youth was linked to decreased stimulated production of IL-5 (r = -0.46, p = .002) and IL-13 (r = -0.37, p = .014). Total negative affect among youth was unrelated to immune responses. There was a significant indirect effect of maternal responsiveness via positive affect in youth on lower levels of IL-5 (95% confidence interval = -3.41 to -0.03) and IL-13 (95% confidence interval = -2.34 to -0.01) when adjusting for caregiver-youth conflict and negative affect among youth.

conclusionsThese results indicate the importance of positive family interactions for youth and provide preliminary evidence for a mechanism through which parenting can influence immune responses in youth with asthma.

Indexed as

Mother-Child RelationsAdolescentAsthmaChildFemaleHumansInterferon-gammaInterleukin-13Interleukin-5MaleMonitoring, AmbulatoryIL5 protein, humanInterferon-gammaInterleukin-13Interleukin-5

Identifiers

PMID26407226
PMCPMC4641672
OpenAlexW2467712805

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.