ArticlePloS one2015
Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Isolation and Characterization of Antimicrobial Agents From Ipomoea carnea via Bioactivity-Guided Fractionation, Supported by In Vitro and In Silico Studies.Chemistry & biodiversity · 2026Article
- Effects of Fermentation Period on Metabolite Production and Bioactivity in Two Sponge-Associated Bacteria.Scientifica · 2026Article
- Screening of Red Sea- and Mediterranean Sea-derived Actinomycetes for Antimicrobial and Antitumor activities: LC-ESI-HRMS-based Metabolomics Study.Microbial cell factories · 2025Article
- Defining the biomarkers in anti-MRSA fractions of soil Streptomycetes by multivariate analysis.Antonie van Leeuwenhoek · 2025Article
- Biotechnological potential of actinomycetes in the 21st century: a brief review.Antonie van Leeuwenhoek · 2024Review
- Targeting antimalarial metabolites from the actinomycetes associated with the Red Sea sponge Callyspongia siphonella using a metabolomic method.BMC microbiology · 2023Article
- Prioritization of Microorganisms Isolated from the Indian Ocean SpongeMicroorganisms · 2023Article
- Use of soil actinomycetes for pharmaceutical, food, agricultural, and environmental purposes.3 Biotech · 2022Review
- Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease-A Systematic Literature Review.Antibiotics (Basel, Switzerland) · 2022Review
- Fungicide Activity of Culture Extract fromJournal of fungi (Basel, Switzerland) · 2022Article
- Anti-cancer and antimicrobial potential of five soilRoyal Society open science · 2022Article
- Metabolomics Tools Assisting Classic Screening Methods in Discovering New Antibiotics from Mangrove Actinomycetia in Leizhou Peninsula.Marine drugs · 2021Article
- Sponge-associated spSaudi journal of biological sciences · 2021Article
- Insights into the Variation in Bioactivities of Closely RelatedMarine drugs · 2021Article
- A metabolomic approach to target antimalarial metabolites in the Artemisia annua fungal endophytes.Scientific reports · 2021Article
- Phylogenetic diversity and activity screening of cultivable Actinobacteria isolated from marine sponges and associated environments from the western coast of India.Access microbiology · 2021Article
- Actinomycetes from the Red Sea SpongeMicroorganisms · 2020Article
- Metagenomics Approaches in Discovery and Development of New Bioactive Compounds from Marine Actinomycetes.Current microbiology · 2020Review
- Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria.Marine drugs · 2020Review
- Recent metabolomics and gene editing approaches for synthesis of microbial secondary metabolites for drug discovery and development.World journal of microbiology & biotechnology · 2019Review
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Marine sponge-associated actinomycetes are considered as promising sources for the discovery of novel biologically active compounds. In the present study, a total of 64 actinomycetes were isolated from 12 different marine sponge species that had been collected offshore the islands of Milos and Crete, Greece, eastern Mediterranean. The isolates were affiliated to 23 genera representing 8 different suborders based on nearly full length 16S rRNA gene sequencing. Four putatively novel species belonging to genera Geodermatophilus, Microlunatus, Rhodococcus and Actinomycetospora were identified based on a 16S rRNA gene sequence similarity of < 98.5% to currently described strains. Eight actinomycete isolates showed bioactivities against Trypanosma brucei brucei TC221 with half maximal inhibitory concentration (IC50) values <20 μg/mL. Thirty four isolates from the Milos collection and 12 isolates from the Crete collection were subjected to metabolomic analysis using high resolution LC-MS and NMR for dereplication purposes. Two isolates belonging to the genera Streptomyces (SBT348) and Micromonospora (SBT687) were prioritized based on their distinct chemistry profiles as well as their anti-trypanosomal activities. These findings demonstrated the feasibility and efficacy of utilizing metabolomics tools to prioritize chemically unique strains from microorganism collections and further highlight sponges as rich source for novel and bioactive actinomycetes.
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