Evidence map›Paper›PMID 26407127›Full record

ArticlePLoS computational biology2015

miRTex: A Text Mining System for miRNA-Gene Relation Extraction.

Gang Li, Karen E Ross, Cecilia N Arighi, Yifan Peng, Cathy H Wu, K Vijay-Shanker

Abstract read
In one paragraph

Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Article
  8. Review
  9. Article
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  12. emiRIT: a text-mining-based resource for microRNA information.Database : the journal of biological databases and curation · 2021
    Article
  13. Article
  14. Constructing knowledge graphs and their biomedical applications.Computational and structural biotechnology journal · 2020
    Review
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gang LiDepartment of Computer and Information Sciences, University of Delaware, Newark, Delaware, United States of America.
Karen E RossDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, United States of America; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, United States of America.
Cecilia N ArighiCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, United States of America.
Yifan PengDepartment of Computer and Information Sciences, University of Delaware, Newark, Delaware, United States of America.
Cathy H WuDepartment of Computer and Information Sciences, University of Delaware, Newark, Delaware, United States of America; Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, United States of America; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, Delaware, United States of America.
K Vijay-ShankerDepartment of Computer and Information Sciences, University of Delaware, Newark, Delaware, United States of America.

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026
$67.2M
NIGMS NIH HHS P20 GM103446
6 · The paper itself

Abstract

MicroRNAs (miRNAs) regulate a wide range of cellular and developmental processes through gene expression suppression or mRNA degradation. Experimentally validated miRNA gene targets are often reported in the literature. In this paper, we describe miRTex, a text mining system that extracts miRNA-target relations, as well as miRNA-gene and gene-miRNA regulation relations. The system achieves good precision and recall when evaluated on a literature corpus of 150 abstracts with F-scores close to 0.90 on the three different types of relations. We conducted full-scale text mining using miRTex to process all the Medline abstracts and all the full-length articles in the PubMed Central Open Access Subset. The results for all the Medline abstracts are stored in a database for interactive query and file download via the website at http://proteininformationresource.org/mirtex. Using miRTex, we identified genes potentially regulated by miRNAs in Triple Negative Breast Cancer, as well as miRNA-gene relations that, in conjunction with kinase-substrate relations, regulate the response to abiotic stress in Arabidopsis thaliana. These two use cases demonstrate the usefulness of miRTex text mining in the analysis of miRNA-regulated biological processes.

Indexed as

Computational BiologyDatabases, GeneticData MiningGenesHumansMicroRNAsModels, GeneticPeriodicals as TopicMicroRNAs

Identifiers

PMID26407127
PMCPMC4583433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.