ArticlePloS one2015
Modulation of Locomotion and Reproduction by FLP Neuropeptides in the Nematode Caenorhabditis elegans.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Intrinsic and non-cell-autonomous roles for the neurodevelopmental syndrome-linked transcription factor UNC-3/EBF.Nature communications · 2026Article
- The FMRFamide-like peptide FLP-11 regulates the production and secretion of the TGF-β-like protein DAF-7 during Caenorhabditis elegans larval development.Scientific reports · 2026Article
- Intrinsic and non-cell autonomous roles for a neurodevelopmental syndrome-linked transcription factor.bioRxiv : the preprint server for biology · 2025Article
- Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior.Genetics · 2024Review
- A molecular atlas of adult C. elegans motor neurons reveals ancient diversity delineated by conserved transcription factor codes.Cell reports · 2024Article
- A molecular atlas of adultbioRxiv : the preprint server for biology · 2023Article
- Identification and Characterization ofBiomolecules · 2023Article
- Disexcitation in the ASH/RIM/ADL negative feedback circuit fine-tunes hyperosmotic sensation and avoidance inFrontiers in molecular neuroscience · 2023Article
- Co-transmission of neuropeptides and monoamines choreograph the C. elegans escape response.PLoS genetics · 2022Article
- Distinct neuropeptide-receptor modules regulate a sex-specific behavioral response to a pheromone.Communications biology · 2021Article
- Background mutation in strain RB2126 affects the locomotion behavior ofmicroPublication biology · 2021Article
- Identification of Low Molecular Weight Proteins and Peptides fromBiomolecules · 2021Article
- Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs.Frontiers in molecular neuroscience · 2021Review
- Control of Locomotory Behavior ofGenetics · 2020Article
- Host-Induced Silencing of FMRFamide-Like Peptide Genes,Frontiers in plant science · 2020Article
- Simultaneous RNAi Knockdown of Three FMRFamide-Like Peptide Genes,Frontiers in microbiology · 2020Article
- Neuropeptides encoded byPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- FLP-18 Functions through the G-Protein-Coupled Receptors NPR-1 and NPR-4 to Modulate Reversal Length inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Mass spectrometric evidence for neuropeptide-amidating enzymes inThe Journal of biological chemistry · 2018Article
- FLP-1 neuropeptides modulate sensory and motor circuits in the nematode Caenorhabditis elegans.PloS one · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Neuropeptides function in animals to modulate most, if not all, complex behaviors. In invertebrates, neuropeptides can function as the primary neurotransmitter of a neuron, but more generally they co-localize with a small molecule neurotransmitter, as is commonly seen in vertebrates. Because a single neuron can express multiple neuropeptides and because neuropeptides can bind to multiple G protein-coupled receptors, neuropeptide actions increase the complexity by which the neural connectome can be activated or inhibited. Humans are estimated to have 90 plus neuropeptide genes; by contrast, nematodes, a relatively simple organism, have a slightly larger complement of neuropeptide genes. For instance, the nematode Caenorhabditis elegans has over 100 neuropeptide-encoding genes, of which at least 31 genes encode peptides of the FMRFamide family. To understand the function of this large FMRFamide peptide family, we isolated knockouts of different FMRFamide-encoding genes and generated transgenic animals in which the peptides are overexpressed. We assayed these animals on two basic behaviors: locomotion and reproduction. Modulating levels of different neuropeptides have strong as well as subtle effects on these behaviors. These data suggest that neuropeptides play critical roles in C. elegans to fine tune neural circuits controlling locomotion and reproduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.