ArticlePloS one2015
The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- A review of the Augustine blood group system.International journal of hematology · 2024Review
- Novel variants provide differential stabilisation of human equilibrative nucleoside transporter 1 states.Frontiers in molecular biosciences · 2022Article
- Insight into the nucleoside transport and inhibition of human ENT1.Current research in structural biology · 2022Article
- Toward a Molecular Basis of Cellular Nucleoside Transport in Humans.Chemical reviews · 2021Review
- IMPROvER: the Integral Membrane Protein Stability Selector.Scientific reports · 2020Article
- Equilibrative Nucleoside Transporter 2: Properties and Physiological Roles.BioMed research international · 2020Review
- Functional Expression of the Human Glucose Transporters GLUT2 and GLUT3 in Yeast Offers Novel Screening Systems for GLUT-Targeting Drugs.Frontiers in molecular biosciences · 2020Article
- Structures of human ENT1 in complex with adenosine reuptake inhibitors.Nature structural & molecular biology · 2019Article
- Identification of Structural and Molecular Features Involved in the Transport of 3'-Deoxy-Nucleoside Analogs by Human Equilibrative Nucleoside Transporter 3.Drug metabolism and disposition: the biological fate of chemicals · 2018Article
- Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy.Scientific reports · 2017Article
- Functional characterization of human equilibrative nucleoside transporter 1.Protein & cell · 2017Article
- Equilibrative nucleoside transporters-A review.Nucleosides, nucleotides & nucleic acids · 2017Review
- N-linked glycosylation of N48 is required for equilibrative nucleoside transporter 1 (ENT1) function.Bioscience reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Equilibrative nucleoside transporters (ENTs) are integral membrane proteins, which reside in plasma membranes of all eukaryotic cells and mediate thermodynamically downhill transport of nucleosides. This process is essential for nucleoside recycling, and also plays a key role in terminating adenosine-mediated cellular signaling. Furthermore, ENTs mediate the uptake of many drugs, including anticancer and antiviral nucleoside analogues. The structure and mechanism, by which ENTs catalyze trans-membrane transport of their substrates, remain unknown. To identify the core of the transporter needed for stability, activity, and for its correct trafficking to the plasma membrane, we have expressed human ENT deletion mutants in Xenopus laevis oocytes and determined their localization, transport properties and susceptibility to inhibition. We found that the carboxyl terminal trans-membrane segments are essential for correct protein folding and trafficking. In contrast, the soluble extracellular and intracellular loops appear to be dispensable, and must be involved in the fine-tuning of transport regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.