Evidence map›Paper›PMID 26406969›Full record

ArticleJournal of affective disorders2016

Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents.

Jie-Yu Chuang, Kirstie J Whitaker, Graham K Murray, Rebecca Elliott, Cindy C Hagan, Julia Me Graham, Cinly Ooi, Roger Tait, Rosemary J Holt, Adrienne O van Nieuwenhuizen and 7 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Jie-Yu ChuangDepartment of Psychiatry, University of Cambridge. Electronic address: jc756@cam.ac.uk.
Kirstie J WhitakerDepartment of Psychiatry, University of Cambridge.
Graham K MurrayDepartment of Psychiatry, University of Cambridge; Behavioural and Clinical Neuroscience Institute, University of Cambridge; Cambridgeshire and Peterborough NHS Foundation Trust.
Rebecca ElliottInstitute of Brain, Behaviour and Mental Health, University of Manchester.
Cindy C HaganDepartment of Psychiatry, University of Cambridge; Department of Psychology, Columbia University.
Julia Me GrahamDepartment of Psychiatry, University of Cambridge.
Cinly OoiDepartment of Psychiatry, University of Cambridge.
Roger TaitBehavioural and Clinical Neuroscience Institute, University of Cambridge.
Rosemary J HoltDepartment of Psychiatry, University of Cambridge.
Adrienne O van NieuwenhuizenUniversity of Cambridge.
Shirley ReynoldsSchool of psychology and Clinical language Sciences, University of Reading.
Paul O WilkinsonDepartment of Psychiatry, University of Cambridge.
Edward T BullmoreDepartment of Psychiatry, University of Cambridge.
Belinda R LennoxDepartment of Psychiatry, University of Oxford.
Barbara J SahakianDepartment of Psychiatry, University of Cambridge; Behavioural and Clinical Neuroscience Institute, University of Cambridge.
Ian GoodyerDepartment of Psychiatry, University of Cambridge.
John SucklingDepartment of Psychiatry, University of Cambridge; Behavioural and Clinical Neuroscience Institute, University of Cambridge; Cambridgeshire and Peterborough NHS Foundation Trust.
University of Cambridge · GBNeuroscience Institute · ITCambridgeshire and Peterborough NHS Foundation Trust · GBUniversity of Manchester · GBUniversity of Oxford · GBUniversity of Reading · GB

Funding

Department of Health 06/05/01Department of Health 97/29/01Medical Research Council G0001354Medical Research Council G0802226Medical Research Council G1000183Wellcome Trust 093875Wellcome Trust 095844
6 · The paper itself

Abstract

backgroundDepression in adolescence is debilitating with high recurrence in adulthood, yet its pathophysiological mechanism remains enigmatic. To examine the interaction between emotion, cognition and treatment, functional brain responses to sad and happy distractors in an affective go/no-go task were explored before and after Cognitive Behavioural Therapy (CBT) in depressed female adolescents, and healthy participants.

methodsEighty-two Depressed and 24 healthy female adolescents, aged 12-17 years, performed a functional magnetic resonance imaging (fMRI) affective go/no-go task at baseline. Participants were instructed to withhold their responses upon seeing happy or sad words. Among these participants, 13 patients had CBT over approximately 30 weeks. These participants and 20 matched controls then repeated the task.

resultsAt baseline, increased activation in response to happy relative to neutral distractors was observed in the orbitofrontal cortex in depressed patients which was normalised after CBT. No significant group differences were found behaviourally or in brain activation in response to sad distractors. Improvements in symptoms (mean: 9.31, 95% CI: 5.35-13.27) were related at trend-level to activation changes in orbitofrontal cortex. LIMITATIONS: In the follow-up section, a limited number of post-CBT patients were recruited.

conclusionsTo our knowledge, this is the first fMRI study addressing the effect of CBT in adolescent depression. Although a bias toward negative information is widely accepted as a hallmark of depression, aberrant brain hyperactivity to positive distractors was found and normalised after CBT. Research, assessment and treatment focused on positive stimuli could be a future consideration. Moreover, a pathophysiological mechanism distinct from adult depression may be suggested and awaits further exploration.

Indexed as

AdolescentAttentionBrainCognitive Behavioral TherapyDepressionEmotionsFemaleHappinessHumansMagnetic Resonance ImagingPhotic StimulationPrefrontal CortexTreatment OutcomeAdolescent depressionCognitive behaviour therapyFunctional magnetic resonance imagingPositive stimuli

Identifiers

PMID26406969
PMCPMC4650987
OpenAlexW2104510751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.