Observational studyPloS one2015
Excessive Weight Gain during the First Year of Peritoneal Dialysis Is Associated with Inflammation, Diabetes Mellitus, and a Rapid Decrease in Residual Renal Function.
Observational study in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Influencing factors for residual kidney function in incident peritoneal dialysis patients: a systematic review and meta-analysis.Renal failure · 2023Pooled it
- AQP7 deficiency drives adipose tissue remodeling and disrupts homeostasis.npj metabolic health and disease · 2025Article
- Impact of Weight Gain on the Subsequent Survival of New Peritoneal Dialysis Patients.Kidney diseases (Basel, Switzerland) · 2023Article
- Elevated Ferritin Levels Associated with High Body Fat Mass Affect Mortality in Peritoneal Dialysis Patients.Nutrients · 2023Article
- On the importance of the interplay of residual renal function with clinical outcomes in end-stage kidney disease.Journal of nephrology · 2022Review
- Adipose and Plasma microRNAs miR-221 and 222 Associate with Obesity, Insulin Resistance, and New Onset Diabetes after Peritoneal Dialysis.Nutrients · 2022Article
- Obesity, Weight Gain, and Fluid Overload in Peritoneal Dialysis.Frontiers in nephrology · 2022Review
- Clinical value of body composition monitor to evaluate lean and fat tissue mass in peritoneal dialysis.European journal of clinical nutrition · 2019Observational
- Advances in Understanding and Management of Residual Renal Function in Patients with Chronic Kidney Disease.Kidney diseases (Basel, Switzerland) · 2017Review
- Peritoneal dialysis influences microRNA expression and pro-inflammatory response: results from a cross-sectional study.Jornal brasileiro de nefrologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSignificant weight gain is a potential problem in most patients starting peritoneal dialysis (PD); however, few studies have explored the clinical effects of increased body weight (BW) in these patients. We evaluated the effect of excess weight gain during the first year after PD on residual renal function (RRF).
methodsA total of 148 incident PD patients were analyzed in a longitudinal observational study. The mean duration of follow-up was 23.8 months. RRF was measured at baseline (within 1 month of starting PD) and thereafter at 6-month intervals for 2-3 years or until loss of RRF. BW was measured at the time of RRF measurement, and excess weight gain was defined as a BW increase over the median value (3.0%).
resultsThe median 1-year increase in BW was 2.3kg (IQR, 1.01-4.58) or 3.0% (IQR, 1.13-5.31). The mean slope of RRF decline was -0.068 ± 0.053 mL/min/month/1.73m2, and RRF loss developed in 48 patients at a mean follow-up time of 19.4 ± 6.8 months. Patients with BW increases > 3.0% showed significantly increased RRF decline rate compared to those without excess weight gain (p<0.001), and the BW increase (%/year) correlated significantly with higher hs-CRP levels and RRF decline rate. High systolic blood pressure, diabetes, large amount of proteinuria and excess BW gain significantly influenced the RRF decline rate. Also, it increased the risk of RRF loss by 4.17-fold (95% confidence intervals, 1.87-9.28; p<0.001).
conclusionsExcess weight gain during the first year of PD was closely linked to systemic inflammation, diabetes and rapid decline in RRF.
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Registered trials
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