ArticlePloS one2015
Identification of Loci Associated with Drought Resistance Traits in Heterozygous Autotetraploid Alfalfa (Medicago sativa L.) Using Genome-Wide Association Studies with Genotyping by Sequencing.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- Recent advances in breeding systems and their improvement in forage crops.Molecular biology reports · 2025Review
- Advances in basic biology of alfalfa (Horticulture research · 2025Article
- Integrative analysis of seed morphology, geographic origin, and genetic structure in Medicago with implications for breeding and conservation.BMC plant biology · 2025Article
- Genome-Wide Association and Genomic Prediction of Alfalfa (International journal of molecular sciences · 2025Article
- Article
- Analyzing Medicago spp. seed morphology using GWAS and machine learning.Scientific reports · 2024Article
- Pearl millet a promising fodder crop for changing climate: a review.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Crop Landraces and Indigenous Varieties: A Valuable Source of Genes for Plant Breeding.Plants (Basel, Switzerland) · 2024Review
- Discovering new genes for alfalfa (Frontiers in plant science · 2024Article
- Molecular mechanisms of drought resistance using genome-wide association mapping in maize (Zea mays L.).BMC plant biology · 2023Article
- Sustainable Innovation: Turning Waste into Soil Additives.Materials (Basel, Switzerland) · 2023Article
- Transcriptome and GWAS Analyses Reveal Candidate Gene for Root Traits of Alfalfa during Germination under Salt Stress.International journal of molecular sciences · 2023Article
- Application of machine learning to explore the genomic prediction accuracy of fall dormancy in autotetraploid alfalfa.Horticulture research · 2023Article
- Alfalfa genomic selection for different stress-prone growing regions.The plant genome · 2022Article
- Review
- Validation of DNA marker-assisted selection for forage biomass productivity under deficit irrigation in alfalfa.The plant genome · 2022Article
- Genome Assembly of Alfalfa Cultivar Zhongmu-4 and Identification of SNPs Associated with Agronomic Traits.Genomics, proteomics & bioinformatics · 2022Article
- Identification of QTL and candidate genes associated with biomass yield and Feed Quality in response to water deficit in alfalfa (Frontiers in plant science · 2022Article
- A Genome-Wide Association Study Coupled With a Transcriptomic Analysis Reveals the Genetic Loci and Candidate Genes Governing the Flowering Time in Alfalfa (Frontiers in plant science · 2022Article
- Intraspecific Variation for Leaf Physiological and Root Morphological Adaptation to Drought Stress in Alfalfa (Frontiers in plant science · 2022Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drought resistance is an important breeding target for enhancing alfalfa productivity in arid and semi-arid regions. Identification of genes involved in drought tolerance will facilitate breeding for improving drought resistance and water use efficiency in alfalfa. Our objective was to use a diversity panel of alfalfa accessions comprised of 198 cultivars and landraces to identify genes involved in drought tolerance. The panel was selected from the USDA-ARS National Plant Germplasm System alfalfa collection and genotyped using genotyping by sequencing. A greenhouse procedure was used for phenotyping two important traits associated with drought tolerance: drought resistance index (DRI) and relative leaf water content (RWC). Marker-trait association identified nineteen and fifteen loci associated with DRI and RWC, respectively. Alignments of target sequences flanking to the resistance loci against the reference genome of M. truncatula revealed multiple chromosomal locations. Markers associated with DRI are located on all chromosomes while markers associated with RWC are located on chromosomes 1, 2, 3, 4, 5, 6 and 7. Co-localizations of significant markers between DRI and RWC were found on chromosomes 3, 5 and 7. Most loci associated with DRI in this work overlap with the reported QTLs associated with biomass under drought in alfalfa. Additional significant markers were targeted to several contigs with unknown chromosomal locations. BLAST search using their flanking sequences revealed homology to several annotated genes with functions in stress tolerance. With further validation, these markers may be used for marker-assisted breeding new alfalfa varieties with drought resistance and enhanced water use efficiency.
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