Trial reportPloS one2015
Do Sustained Lung Inflations during Neonatal Resuscitation Affect Cerebral Blood Volume in Preterm Infants? A Randomized Controlled Pilot Study.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 10 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 9. Neonatal resuscitation.Clinical and experimental emergency medicine · 2026Guideline
- Cerebral oxygenation measurements during immediate neonatal transition in the delivery room: a systematic review.Pediatric research · 2026Pooled it
- Sustained versus standard inflations during neonatal resuscitation to prevent mortality and improve respiratory outcomes.The Cochrane database of systematic reviews · 2025Pooled it
- Interventions to Reduce Severe Brain Injury Risk in Preterm Neonates: A Systematic Review and Meta-analysis.JAMA network open · 2023Pooled it
- 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 8. Neonatal resuscitation.Clinical and experimental emergency medicine · 2021Guideline
- Sustained Inflation vs Standard Resuscitation for Preterm Infants: A Systematic Review and Meta-analysis.JAMA pediatrics · 2020Pooled it
- Sustained versus standard inflations during neonatal resuscitation to prevent mortality and improve respiratory outcomes.The Cochrane database of systematic reviews · 2020Pooled it
- [Application of sustained lung inflation in preterm infants with a gestational age of <34 weeks: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Pooled it
- Improving Newborn Respiratory Outcomes With a Sustained Inflation: A Systematic Narrative Review of Factors Regulating Outcome in Animal and Clinical Studies.Frontiers in pediatrics · 2020Pooled it
- Sustained versus standard inflations during neonatal resuscitation to prevent mortality and improve respiratory outcomes.The Cochrane database of systematic reviews · 2017Pooled it
- Trial
- Trial
- Hemodynamics and cerebral oxygenation in the neonatal transition: a prospective pilot study.Clinical and experimental pediatrics · 2026Article
- Hemodynamic Changes in the Transition Period in the Preterm and Term Infant: Basic Concepts.Turkish archives of pediatrics · 2025Article
- Fetal to neonatal transition: what additional information can be provided by cerebral near infrared spectroscopy?Pediatric research · 2024Review
- Effect of the change of mechanical ventilation mode on cerebral oxygen saturation level in neonates.BMC pediatrics · 2023Observational
- Aeration strategy at birth does not impact carotid haemodynamics in preterm lambs.Pediatric research · 2023Article
- Cerebral oxygenation immediately after birth and long-term outcome in preterm neonates-a retrospective analysis.BMC pediatrics · 2023Article
- Does physiological-based cord clamping improve cerebral tissue oxygenation and perfusion in healthy term neonates? - A randomized controlled trial.Frontiers in pediatrics · 2022Article
- Correlation between arterial blood pressures and regional cerebral oxygen saturation in preterm neonates during postnatal transition-an observational study.Frontiers in pediatrics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSustained lung inflations (SLI) during neonatal resuscitation may promote alveolar recruitment in preterm infants. While most of the studies focus on respiratory outcome, the impact of SLI on the brain hasn't been investigated yet.
objectiveDo SLI affect cerebral blood volume (CBV) in preterm infants?
methodsPreterm infants of gestation 28 weeks 0 days to 33 weeks 6 days with requirement for respiratory support (RS) were included in this randomized controlled pilot trial. Within the first 15 minutes after birth near-infrared spectroscopy (NIRS) measurements using 'NIRO-200-NX' (Hamamatsu, Japan) were performed to evaluate changes in CBV and cerebral tissue oxygenation. Two groups were compared based on RS: In SLI group RS was given by applying 1-3 SLI (30 cmH2O for 15 s) continued by respiratory standard care. Control group received respiratory standard care only.
results40 infants (20 in each group) with mean gestational age of 32 weeks one day (±2 days) and birth weight of 1707 (±470) g were included. In the control group ΔCBV was significantly decreasing, whereas in SLI group ΔCBV showed similar values during the whole period of 15 minutes. Comparing both groups within the first 15 minutes ΔCBV showed a tendency toward different overall courses (p = 0.051).
conclusionThis is the first study demonstrating an impact of SLI on CBV. Further studies are warranted including reconfirmation of the present findings in infants with lower gestational age. Future investigations on SLI should not only focus on respiratory outcome but also on the consequences on the developing brain.
trial registrationGerman Clinical Trials Register DRKS00005161 https://drks-neu.uniklinik-freiburg.de/drks_web/setLocale_EN.do.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.