Evidence map›Paper›PMID 26406446›Full record

ArticlePloS one2015

Impact of Spectral Notch Width on Neurophysiological Plasticity and Clinical Effectiveness of the Tailor-Made Notched Music Training.

Robert Wunderlich, Pia Lau, Alwina Stein, Alva Engell, Andreas Wollbrink, Claudia Rudack, Christo Pantev

Open access · goldAbstract readComparative Study
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. A Randomized, Controlled Trial of Notched Music Therapy for Tinnitus Patients.The journal of international advanced otology · 2021
    Trial
  2. Trial
  3. Music Therapy and Tinnitus Treatment: Systematic Review and Meta-Analysis.International archives of otorhinolaryngology · 2026
    Review
  4. Article
  5. Eavesdropping on Tinnitus Using MEG: Lessons Learned and Future Perspectives.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
  6. Article
  7. [Mechanism and research progresses of personalized music in the treatment of tinnitus].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Robert WunderlichInstitute for Biomagnetism and Biosignalanalysis, University Hospital of Münster, Münster, Germany; Institute for Physiological Psychology, University of Bielefeld, Bielefeld, Germany.
Pia LauInstitute for Biomagnetism and Biosignalanalysis, University Hospital of Münster, Münster, Germany.
Alwina SteinInstitute for Biomagnetism and Biosignalanalysis, University Hospital of Münster, Münster, Germany.
Alva EngellInstitute for Biomagnetism and Biosignalanalysis, University Hospital of Münster, Münster, Germany.
Andreas WollbrinkInstitute for Biomagnetism and Biosignalanalysis, University Hospital of Münster, Münster, Germany.
Claudia RudackDepartment of Otolaryngology, University Hospital of Münster, Münster, Germany.
Christo PantevInstitute for Biomagnetism and Biosignalanalysis, University Hospital of Münster, Münster, Germany.
University Hospital Münster · DEBielefeld University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tinnitus, the ringing in the ears that is unrelated to any external source, causes a significant loss in quality of life, involving sleep disturbance and depression for 1 to 3% of the general population. While in the first place tinnitus may be triggered by damage to the inner ear cells, the neural generators of subjective tinnitus are located in central regions of the nervous system. A loss of lateral inhibition, tonotopical reorganization and a gain-increase in response to the sensory deprivation result in hypersensitivity and hyperactivity in certain regions of the auditory cortex. In the tailor-made notched music training (TMNMT) patients listen to music from which the frequency spectrum of the tinnitus has been removed. This evokes strong lateral inhibition from neurons tuned to adjacent frequencies onto the neurons involved in the tinnitus percept. A reduction of tinnitus loudness and tinnitus-related neural activity was achieved with TMNMT in previous studies. As the effect of lateral inhibition depends on the bandwidth of the notch, in the current study we altered the notch width to find the most effective notch width for TMNMT. We compared 1-octave notch width with ½-octave and ¼-octave. Participants chose their favorite music for the training that included three month of two hours daily listening. The outcome was measured by means of standardized questionnaires and magnetoencephalography. We found a general reduction of tinnitus distress in all administered tinnitus questionnaires after the training. Additionally, tinnitus-related neural activity was reduced after the training. Nevertheless, notch width did not have an influence on the behavioral or neural effects of TMNMT. This could be due to a non-linear resolution of lateral inhibition in high frequencies.

Indexed as

Evoked Potentials, AuditoryNeuronal PlasticityAcoustic StimulationAdultAuditory PerceptionDouble-Blind MethodFemaleHumansMagnetoencephalographyMaleMiddle AgedMusic TherapyRandom AllocationSurveys and QuestionnairesTinnitusTreatment Outcome

Identifiers

PMID26406446
PMCPMC4583393
OpenAlexW2186541643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.