Evidence map›Paper›PMID 26406293›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2015

Is Anti-Müllerian Hormone Associated With Fecundability? Findings From the EAGeR Trial.

Shvetha M Zarek, Emily M Mitchell, Lindsey A Sjaarda, Sunni L Mumford, Robert M Silver, Joseph B Stanford, Noya Galai, Mark V White, Karen C Schliep, Alan H DeCherney and 1 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00467363 (The Effects of Aspirin in Gestation and Reproduction), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00467363 nacompletednot on this map

The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.

TypeinterventionalSponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Ran2007 to 2012Enrolled1,228ConditionsBirth, Spontaneous AbortionArmsacetylsalicylic-acid (aspirin), Folic acid
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Shvetha M ZarekEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Emily M MitchellEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Lindsey A SjaardaEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Sunni L MumfordEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Robert M SilverEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Joseph B StanfordEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Noya GalaiEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Mark V WhiteEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Karen C SchliepEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Alan H DeCherneyEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Enrique F SchistermanEpidemiology Branch (S.M.Z., E.M.M., L.A.S., S.L.M., K.C.S., E.F.S.), Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20854; Program in Reproductive and Adult Endocrinology (S.M.Z., A.H.D.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20982; Department of Obstetrics and Gynecology (R.M.S., J.B.S.), University of Utah and Intermountain HealthCare, Salt Lake City, Utah 84111; Department of Statistics (N.G.), University of Haifa, Haifa 3498838, Israel; and Department of Family, Community, and Rural Health (M.V.W.), The Commonwealth Medical College, Scranton, Pennsylvania 18509.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USIntermountain Healthcare · USCommonwealth Medical College · USUniversity of Haifa · IL

Funding

Intramural NIH HHSPHS HHS HHSN267200603423PHS HHS HHSN267200603424PHS HHS HHSN267200603426
6 · The paper itself

Abstract

objectiveThe objective of the study was to evaluate whether anti-Müllerian hormone (AMH) is associated with fecundability among women with proven fecundity and a history of pregnancy loss.

designThis was a prospective cohort study within a multicenter, block-randomized, double-blind, placebo-controlled clinical trial ( clinicaltrials.gov , number NCT00467363).

settingThe study was conducted at four US medical centers (2006-2012).

participantsParticipating women were aged 18-40 years, with a history of one to two pregnancy losses who were actively attempting pregnancy.

main outcome measuresTime to human chorionic gonadotropin detected and clinical pregnancy were assessed using Cox proportional hazard regression models to estimate fecundability odds ratios (fecundability odds ratios with 95% confidence interval [CI]) adjusted for age, race, body mass index, income, low-dose aspirin treatment, parity, number of previous losses, and time since most recent loss. Analyses examined by preconception AMH levels: low (<1.00 ng/mL, n = 124); normal (referent 1.00-3.5 ng/mL, n = 595); and high (>3.5 ng/mL, n = 483).

resultsOf the 1202 women with baseline AMH levels, 82 women with low AMH (66.1%) achieved an human chorionic gonadotropin detected pregnancy, compared with 383 with normal AMH (65.2%) and 315 with high AMH level (65.2%). Low or high AMH levels relative to normal AMH (referent) were not associated with fecundability (low AMH: fecundability odds ratios 1.13, 95% CI 0.85-1.49; high AMH: FOR 1.04, 95% CI 0.87-1.24).

conclusionsLower and higher AMH values were not associated with fecundability in unassisted conceptions in a cohort of fecund women with a history of one or two prior losses. Our data do not support routine AMH testing for preconception counseling in young, fecund women.

Indexed as

Abortion, SpontaneousAdolescentAdultAnti-Mullerian HormoneBiomarkersCohort StudiesDouble-Blind MethodFemaleFertilityHumansPredictive Value of TestsPregnancyProspective StudiesSocioeconomic FactorsTreatment OutcomeYoung AdultAnti-Mullerian HormoneBiomarkers

Identifiers

PMID26406293
PMCPMC4702454
OpenAlexW2103342823

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.