ArticlePloS one2015
Use of Antibiotics in Pediatrics: 8-Years Survey in Italian Hospitals.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
- Study of antibiotic consumption using a novel unit among indoor pediatric patients in India.Bioinformation · 2025Article
- Evaluation of pharmacokinetic target attainment and hematological toxicity of linezolid in pediatric patients.European journal of clinical pharmacology · 2024Observational
- Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013-2020.Infection · 2024Article
- Genetic Variations and Antibiotic-Related Adverse Events.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Retrospective audit of antibiotic use in a university general pediatrics department using hospital pharmacy dispensing data.GMS infectious diseases · 2021Article
- A Novel Metric System to Quantify Antibiotic Consumption in Paediatric Population: A Hospital Based, Biphasic Pilot Study.Discoveries (Craiova, Romania) · 2020Article
- Increasing use of linezolid in a tertiary NICU during a 10-year period: reasons and concerns for the future.Antimicrobial resistance and infection control · 2020Article
- Antimicrobial drug use in the first decade of life influences saliva microbiota diversity and composition.Microbiome · 2020Article
- Antibiotic prescriptions in acute otitis media and pharyngitis in Italian pediatric outpatients.Italian journal of pediatrics · 2019Observational
- Prevalence of antibiotic use in a tertiary care hospital in Italy, 2008-2016.Italian journal of pediatrics · 2019Article
- Estimating global trends in total and childhood antibiotic consumption, 2011-2015.BMJ global health · 2019Article
- Article
- Antibiotic Prescriptions and Prophylaxis in Italian Children. Is It Time to Change? Data from the ARPEC Project.PloS one · 2016Article
- Article
- Adverse Drug Reactions Resulting From the Use of Chiral Medicines Amoxicillin, Amoxicillin-Clavulanic Acid, and Ceftriaxone: A Mixed Prospective-Retrospective Cohort Study.Inquiry : a journal of medical care organization, provision and financingArticle
- Antibiotic Prescription Trends Among Pediatric Patients in Dessie Comprehensive Specialized Hospital, Ethiopia.Sage open pediatricsArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate antibiotic consumption in the pediatric wards of Emilia-Romagna Region, from 2004 to 2011, with a focus on the antibiotics reserved to the most serious infections, and to analyse the ADRs reported for antibiotics by the pediatric wards of Emilia-Romagna hospitals.
methodsReference population was represented by all the patients (0-14 years old) admitted to the pediatric wards of all the hospitals of Emilia-Romagna Region. Drug consumption was expressed as number of DDDs per 100 Bed-Days (BD) and data were analysed by active substance, by therapeutic subgroups or by ward type. The time trends of antibiotic consumption were statistically analysed by linear regression. All the suspected ADR reports associated with antibiotics, reported between January 2004 and December 2011 were drawn by the Italian Spontaneous Reporting Database.
resultsOverall antibiotic consumption showed only a slight increase (p = 0.224). Among the pediatric wards, pediatric surgery showed the highest increase from 2004 to 2011 (p = 0.011). Penicillins and β-lactamase inhibitors was the first therapeutic group with a statistically significant increase over years (p = 0.038), whereas penicillins with extended spectrum presented a statistically significant reduction (p = 0.008). Moreover, only 5 drugs out of the 8 antibiotics reserved to the most serious infections were used. Pharmacovigilance data showed 27 spontaneous ADR reports associated to ATC J01 drugs. Amoxicillin/clavulanic acid had the highest number of ADR reports (n = 7).
conclusionsThe steadily increasing consumption in penicillins and β-lactamase inhibitors, in association with a considerable decrease of plain penicillins, raises a serious concern. Pharmacovigilance reports seem to suggest a safe use of antibiotics in the hospital setting of Emilia-Romagna. Further studies to investigate the reason for prescribing antibiotics in children inpatients are needed.
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