Evidence map›Paper›PMID 26405761›Full record

ArticlePhysics in medicine and biology2015

Continuous MR bone density measurement using water- and fat-suppressed projection imaging (WASPI) for PET attenuation correction in PET-MR.

C Huang, J Ouyang, T G Reese, Y Wu, G El Fakhri, J L Ackerman

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. A CombinedAnnals of biomedical engineering · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

C HuangCenter for Advanced Medical Imaging Sciences, Department of Imaging, Massachusetts General Hospital, Boston, MA 02114, USA.
J OuyangCenter for Advanced Medical Imaging Sciences, Department of Imaging, Massachusetts General Hospital, Boston, MA 02114, USA.
T G ReeseDepartment of Radiology, Harvard Medical School, Boston, MA 02115, USA.
Y WuDepartment of Radiology, Harvard Medical School, Boston, MA 02115, USA.
G El FakhriCenter for Advanced Medical Imaging Sciences, Department of Imaging, Massachusetts General Hospital, Boston, MA 02114, USA.
J L AckermanDepartment of Radiology, Harvard Medical School, Boston, MA 02115, USA.

Funding

Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Quantitative Oncologic PET-MRR01CA165221 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES · 2012 to 2023
$4.7M
Quantitative Simultaneous Cardiac PET-MRR01HL118261 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI OUYANG, JINSONG · 2014 to 2018
$2.6M
Quantitative Cardiac PETR01HL110241 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES · 2011 to 2014
$1.9M
Motion Compensation in Simultaneous PET-MRR21EB012326 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES · 2010 to 2011
$470k
MR micro-coil based motion correction in brain PET-MRR03MH106994 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI OUYANG, JINSONG · 2015 to 2016
$174k
NCI NIH HHS R01 CA165221NCI NIH HHS R01-CA165221NHLBI NIH HHS R01 HL110241NHLBI NIH HHS R01-HL110241NHLBI NIH HHS R01 HL118261NHLBI NIH HHS R01-HL118261NIBIB NIH HHS P41 EB015896NIBIB NIH HHS P41-EB015896NIBIB NIH HHS R21 EB012326NIBIB NIH HHS R21-EB012326NIMH NIH HHS R03 MH106994NIMH NIH HHS R03-MH106994
6 · The paper itself

Abstract

Due to the lack of signal from solid bone in normal MR sequences for the purpose of MR-based attenuation correction, investigators have proposed using the ultrashort echo time (UTE) pulse sequence, which yields signal from bone. However, the UTE-based segmentation approach might not fully capture the intra- and inter-subject bone density variation, which will inevitably lead to bias in reconstructed PET images. In this work, we investigated using the water- and fat-suppressed proton projection imaging (WASPI) sequence to obtain accurate and continuous attenuation for bones. This approach is capable of accounting for intra- and inter-subject bone attenuation variations. Using data acquired from a phantom, we have found that that attenuation correction based on the WASPI sequence is more accurate and precise when compared to either conventional MR attenuation correction or UTE-based segmentation approaches.

Indexed as

Adipose TissueBone and BonesBone DensityHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingPhantoms, ImagingPositron-Emission TomographyWaterWater

Identifiers

PMID26405761
PMCPMC4607313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.