Evidence map›Paper›PMID 26405685›Full record

ArticleNon-coding RNA2015

Repression of RNA Polymerase II Transcription by B2 RNA Depends on a Specific Pattern of Structural Regions in the RNA.

Steven L Ponicsan, Jennifer F Kugel, James A Goodrich

Open access · goldAbstract read
In one paragraph

Article in Non-coding RNA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. mThe EMBO journal · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Steven L PonicsanUniversity of Colorado, Department of Chemistry and Biochemistry, 596 UCB, Boulder, CO 80309, USA.
Jennifer F KugelUniversity of Colorado, Department of Chemistry and Biochemistry, 596 UCB, Boulder, CO 80309, USA.
James A GoodrichUniversity of Colorado, Department of Chemistry and Biochemistry, 596 UCB, Boulder, CO 80309, USA.
University of Colorado Boulder · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Regulation of RNA polymerase ll by small RNAsR01GM068414 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI GOODRICH, JAMES · 2003 to 2018
$5.1M
NCATS NIH HHS UL1 TR001082NIGMS NIH HHS R01 GM068414
6 · The paper itself

Abstract

B2 RNA is a mouse non-coding RNA that binds directly to RNA polymerase II (Pol II) and represses transcription by disrupting critical interactions between the polymerase and promoter DNA. How the structural regions within B2 RNA work together to mediate transcriptional repression is not well understood. To address this question, we systematically deleted structural regions from B2 RNA and determined the effects on transcriptional repression using a highly purified Pol II

Indexed as

B2 RNAnon-coding RNArepressorRNA polymerase IISINEtranscription

Identifiers

PMID26405685
PMCPMC4578731
OpenAlexW1982522886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.