ArticleSpringerPlus2015
Accurate evaluation of axillary sentinel lymph node metastasis using contrast-enhanced ultrasonography with Sonazoid in breast cancer: a preliminary clinical trial.
Article in SpringerPlus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis.World journal of surgical oncology · 2020Pooled it
- The combination of contrast-enhanced ultrasonography with blue dye for sentinel lymph node detection in clinically negative node breast cancer.Archives of gynecology and obstetrics · 2021Trial
- Diagnosis of axillary lymph node metastasis in breast cancer: a systematic review and meta-analysis of the literature on ultrasound and magnetic resonance imaging published from 2014 to 2025.Quantitative imaging in medicine and surgery · 2026Article
- Post-vascular phase of contrast-enhanced ultrasound with perfluorobutane for preoperative evaluation of axillary lymph node status in early-stage breast cancer.La Radiologia medica · 2025Article
- Diagnostic value of different contrast-enhanced ultrasound (CEUS) methods for sentinel lymph node metastasis in patients with breast neoplasms: a meta-analysis and indirect comparison.Quantitative imaging in medicine and surgery · 2025Article
- Prediction of axillary lymph node metastasis using a magnetic resonance imaging radiomics model of invasive breast cancer primary tumor.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Ceusia-Breast: computer-aided diagnosis with contrast enhanced ultrasound image analysis for breast lesions.BMC medical imaging · 2023Article
- Percutaneous Sonazoid-enhanced ultrasonography combined with in vitro verification for detection and characterization of sentinel lymph nodes in early breast cancer.European radiology · 2021Article
- Percutaneous Sonazoid-enhanced ultrasonography combined with in vitro verification for detection and characterization of sentinel lymph nodes in early breast cancer.European radiology · 2021Article
- Comparative study of two contrast agents for intraoperative identification of sentinel lymph nodes in patients with early breast cancer.Gland surgery · 2021Article
- Predictive risk factors for sentinel lymph node metastasis using preoperative contrast-enhanced ultrasound in early-stage breast cancer patients.Gland surgery · 2021Article
- Multimodal photoacoustic imaging as a tool for sentinel lymph node identification and biopsy guidance.Biomedical engineering letters · 2018Review
- Sentinel Lymph Node Characterization with a Dual-Targeted Molecular Ultrasound Contrast Agent.Molecular imaging and biology · 2018Article
- Association between contrast-enhanced ultrasonography and histopathological findings of the metastatic lymph nodes of patients with head and neck cancer: A preliminary study.Oncology letters · 2018Article
- Preoperative prediction of sentinel lymph node metastasis in breast cancer based on radiomics of T2-weighted fat-suppression and diffusion-weighted MRI.European radiology · 2018Article
- Identification of sentinel lymph nodes by contrast-enhanced ultrasonography with Sonazoid in patients with breast cancer: a feasibility study in three hospitals.Cancer medicine · 2017Article
- Axillary Nodal Staging with Contrast-Enhanced Ultrasound.Current breast cancer reports · 2017Review
- Role of contrast-enhanced endoscopic ultrasound in lymph nodes.Endoscopic ultrasoundReview
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is the most common type of cancer in women. The 5-year survival rate in patients with breast cancer ranges from 74 to 82 %. Sentinel lymph node biopsy has become an alternative to axillary lymph node dissection for nodal staging. We evaluated the detection of the sentinel lymph node and metastasis of the lymph node using contrast enhanced ultrasonography with Sonazoid. Between December 2013 and May 2014, 32 patients with operable breast cancer were enrolled in this study. We evaluated the detection of axillary sentinel lymph nodes and the evaluation of axillary lymph nodes metastasis using contrast enhanced computed tomography, color Doppler ultrasonography and contrast enhanced ultrasonography with Sonazoid. All the sentinel lymph nodes were identified, and the sentinel lymph nodes detected by contrast enhanced ultrasonography with Sonazoid corresponded with those detected by computed tomography lymphography and indigo carmine method. The detection of metastasis based on contrast enhanced computed tomography were sensitivity 20.0 %, specificity 88.2 %, PPV 60.0 %, NPV 55.6 %, accuracy 56.3 %. Based on color Doppler ultrasonography, the results were sensitivity 36.4 %, specificity 95.2 %, PPV 80.0 %, NPV 74.1 %, accuracy 75.0 %. Based on contrast enhanced ultrasonography with Sonazoid, the results were sensitivity 81.8 %, specificity 95.2 %, PPV 90.0 %, NPV 90.9 %, accuracy 90.6 %. The results suggested that contrast enhanced ultrasonography with Sonazoid was the most accurate among the evaluations of these modalities. In the future, we believe that our method would take the place of conventional sentinel lymph node biopsy for an axillary staging method.
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