ArticleThe Pan African medical journal2015
Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital.
Article in The Pan African medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Off-Label Use of Tenecteplase for the Treatment of Acute Ischemic Stroke: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Ischemic stroke in Morocco: a systematic review.BMC neurology · 2019Pooled it
- Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke.Journal of the American Heart Association · 2024Review
- [Thrombolysis alert in ischemic stroke: experience of the international private clinic Al Badie in Fez (cross-sectional study of 60 cases)].The Pan African medical journal · 2024Article
- Article
- Intravenous thrombolysis with rt-PA in stroke: experience of the moroccan stroke unit.The Pan African medical journal · 2016Article
- Acute ischemic stroke thrombolysis with tenecteplase: An institutional experience from South India.Annals of African medicineArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThrombolysis has radically changed the prognosis of acute ischemic stroke. Tenecteplase is a modified form of rt-PA with greater specificity for fibrin and a longer half-life. We report the experience of a Moroccan tertiary hospital in thrombolysis using Tenecteplase.
methodsWe conducted an open prospective study of all patients who were treated with Tenecteplase for an acute ischemic stroke admitted to our emergency department. Tenecteplase was administered intravenously at a dose of 0.4 mg/kg single bolus. The primary outcome measure was the proportion of patients achieving significant early neurological recovery defined as an improvement of 4 or more points on the NIHSS score at 24h.
results13 patients had been treated by intravenous thrombolysis. 31% were women. Mean age was 63 years old. The mean NIHSS score at admission was 14.3 and 24h after was at 9.1. The right middle cerebral artery was involved in 69% of cases. The carotid atherosclerosis was predominant 63.3% and the cardio embolic etiology 27%. The mean time to the first medical contact after the onset of symptoms was 3h 30 min. One patient presented a capsulo-lenticular hematoma of 5 mm(3) in the same side of the ischemic stroke.
conclusionTenecteplase is a more interesting thrombolytic than alteplase, it seems to be more suitable for thrombolysis in our center.
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