ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
Prophylactic Antibiotics May Improve Outcome in Patients With Severe Burns Requiring Mechanical Ventilation: Propensity Score Analysis of a Japanese Nationwide Database.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Wound, Pressure Ulcer, and Burn Guidelines (2023)-6: Guidelines for the Management of Burns, Third Edition.The Journal of dermatology · 2026Guideline
- Unprecedented Polymicrobial Bacteremia With Nine Microorganisms in a Critically Ill 95% Burn Patient.Cureus · 2025Article
- Managing Infections in Burn Patients: Strategies and Considerations for Antimicrobial Dosing.European burn journal · 2025Review
- Multidrug-Resistant Organisms: The Silent Plight of Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2024Review
- Antibiotic prophylaxis in injury: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document.Trauma surgery & acute care open · 2024Article
- Analysis of Potential Risk Factors for Multidrug-Resistance at a Burn Unit.European burn journal · 2023Article
- Multidrug-Resistant Pathogens in Burn Wound, Prevention, Diagnosis, and Therapeutic Approaches (Conventional Antimicrobials and Nanoparticles).The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Review
- Association between comprehensive geriatric assessment and polypharmacy at discharge in patients with ischaemic stroke: A nationwide, retrospective, cohort study.EClinicalMedicine · 2022Article
- Reply: Antimicrobial Prophylaxis in Extracorporeal Membrane Oxygenation: Is the Debate Still Open?Annals of the American Thoracic Society · 2022Article
- Hospitalization for urinary tract infections in Japan, 2010-2015: a retrospective study using a national inpatient database.BMC infectious diseases · 2021Observational
- Reverse J-shaped relationship between body mass index and in-hospital mortality of patients hospitalized for heart failure in Japan.Heart and vessels · 2021Article
- Association between the number of hospital admissions and in-hospital outcomes in patients with heart failure.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Management of Thermal Injuries in Donkeys: A Case Report.Animals : an open access journal from MDPI · 2020Article
- Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods.EClinicalMedicine · 2020Article
- After standard dosage of piperacillin plasma concentrations of drug are subtherapeutic in burn patients.Naunyn-Schmiedeberg's archives of pharmacology · 2019Observational
- Volume-outcome relationship on survival and cost benefits in severe burn injury: a retrospective analysis of a Japanese nationwide administrative database.Journal of intensive care · 2019Article
- Adjunctive corticosteroid therapy for inpatients with Mycoplasma pneumoniae pneumonia.BMC pulmonary medicine · 2017Article
- Antithrombin use and 28-day in-hospital mortality among severe-burn patients: an observational nationwide study.Annals of intensive care · 2017Article
- Bacterial Infections After Burn Injuries: Impact of Multidrug Resistance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Review
- Risk factors for delayed oral dietary intake in patients with deep neck infections including descending necrotizing mediastinitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
Corrections and comments
- Commented on by
- Commented on byReply to Hurley.2016
- Commented on by
- Commented on by
- Commented on by
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of prophylactic antibiotics for severe burns in general settings remains controversial and is not suggested by recent guidelines owing to lack of evidence for efficacy. We examined the hypothesis that prophylactic systemic antibiotic therapy may reduce mortality in patients with severe burns.
methodsWe identified 2893 severe burns patients (burn index ≥ 10) treated at 583 hospitals between July 2010 and March 2013 using the Japanese diagnosis procedure combination inpatient database. We categorized the patients according to whether they received mechanical ventilation within 2 days after admission (n = 692) or not (n = 2201). We further divided the patients into those with and without prophylactic antibiotics and generated 232 and 526 propensity score-matched pairs, respectively. We evaluated 28-day all-cause in-hospital mortality.
resultsAmong the mechanically ventilated patients, significant differences in 28-day in-hospital mortality existed between control and prophylaxis groups in both unmatched (control vs prophylaxis; 48.6% vs 38.3%; difference, 10.2%; 95% confidence interval [95% CI], 2.7 to 17.7) and propensity score-matched groups (47.0% vs 36.6%; difference, 10.3%; 95% CI, 1.4 to 19.3). Among patients without mechanical ventilation, there was no significant difference in 28-day in-hospital mortality between the 2 groups in both the unmatched (control vs prophylaxis; 7.0% vs 5.8%; difference, 1.2%; 95% CI, -1.2 to 3.5) and propensity-matched groups (5.1% vs 4.2%; difference, 0.9%; 95% CI, -1.6 to 3.5).
conclusionsProphylactic antibiotics use may result in improved 28-day in-hospital mortality in mechanically ventilated patients with severe burns but not in those who do not receive mechanical ventilation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.