ArticleGenetics2015
A Novel Statistical Model to Estimate Host Genetic Effects Affecting Disease Transmission.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Impact of genomic selection for disease resistance on the spread of infection in a simulated aquaculture population.Genetics, selection, evolution : GSE · 2026Article
- Estimation of Genetic Variance and Breeding Values for Infectious Disease Susceptibility From Simulated Longitudinal Data Using Generalized Linear Mixed Models Based on Transmission Dynamics.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- SIRE 2.0: a novel method for estimating polygenic host effects underlying infectious disease transmission, and analytical expressions for prediction accuracies.Genetics, selection, evolution : GSE · 2025Article
- Disease resistance and infectivity of virus susceptible and resistant common carp strains.Scientific reports · 2024Article
- Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission.Genetics, selection, evolution : GSE · 2022Article
- Review: Livestock disease resilience: from individual to herd level.Animal : an international journal of animal bioscience · 2021Review
- On the origin of the genetic variation in infectious disease prevalence: Genetic analysis of disease status versus infections for Digital Dermatitis in Dutch dairy cattle.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2021Article
- Why genetic selection to reduce the prevalence of infectious diseases is way more promising than currently believed.Genetics · 2021Article
- Estimating individuals' genetic and non-genetic effects underlying infectious disease transmission from temporal epidemic data.PLoS computational biology · 2020Article
- The economic value of RGenetics, selection, evolution : GSE · 2020Article
- Genetic parameters and genomic breeding values for digital dermatitis in Holstein Friesian dairy cattle: host susceptibility, infectivity and the basic reproduction ratio.Genetics, selection, evolution : GSE · 2019Article
- Enhancing genetic disease control by selecting for lower host infectivity and susceptibility.Heredity · 2019Article
- Models with indirect genetic effects depending on group sizes: a simulation study assessing the precision of the estimates of the dilution parameter.Genetics, selection, evolution : GSE · 2019Article
- Genetic differences in host infectivity affect disease spread and survival in epidemics.Scientific reports · 2019Article
- Derivation of the economic value of RGenetics, selection, evolution : GSE · 2018Article
- Can We Breed Cattle for Lower Bovine TB Infectivity?Frontiers in veterinary science · 2018Article
- Impact of Genetic Selection for Increased Cattle Resistance to Bovine Tuberculosis on Disease Transmission Dynamics.Frontiers in veterinary science · 2018Article
- Interaction of direct and social genetic effects with feeding regime in growing rabbits.Genetics, selection, evolution : GSE · 2017Article
- A model to estimate effects of SNPs on host susceptibility and infectivity for an endemic infectious disease.Genetics, selection, evolution : GSE · 2017Article
- Use of multi-trait and random regression models to identify genetic variation in tolerance to porcine reproductive and respiratory syndrome virus.Genetics, selection, evolution : GSE · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
There is increasing recognition that genetic diversity can affect the spread of diseases, potentially affecting plant and livestock disease control as well as the emergence of human disease outbreaks. Nevertheless, even though computational tools can guide the control of infectious diseases, few epidemiological models can simultaneously accommodate the inherent individual heterogeneity in multiple infectious disease traits influencing disease transmission, such as the frequently modeled propensity to become infected and infectivity, which describes the host ability to transmit the infection to susceptible individuals. Furthermore, current quantitative genetic models fail to fully capture the heritable variation in host infectivity, mainly because they cannot accommodate the nonlinear infection dynamics underlying epidemiological data. We present in this article a novel statistical model and an inference method to estimate genetic parameters associated with both host susceptibility and infectivity. Our methodology combines quantitative genetic models of social interactions with stochastic processes to model the random, nonlinear, and dynamic nature of infections and uses adaptive Bayesian computational techniques to estimate the model parameters. Results using simulated epidemic data show that our model can accurately estimate heritabilities and genetic risks not only of susceptibility but also of infectivity, therefore exploring a trait whose heritable variation is currently ignored in disease genetics and can greatly influence the spread of infectious diseases. Our proposed methodology offers potential impacts in areas such as livestock disease control through selective breeding and also in predicting and controlling the emergence of disease outbreaks in human populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.