Evidence map›Paper›PMID 26404954›Full record

Trial reportDrug and alcohol dependence2015

A randomized controlled trial of the effects of working memory training in methadone maintenance patients.

Olga Rass, Rebecca L Schacht, Katherine Buckheit, Matthew W Johnson, Eric C Strain, Miriam Z Mintzer

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05879198 (Train Your Brain), which is not on this map. Cited by 46 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05879198 nacompletednot on this mapstarted 2023, after this paper: background citation

Train Your Brain: A Pilot Project to Improve Memory and Decision Making to Improve Outcomes Among Youth

TypeinterventionalSponsorHenry Ford Health SystemRan2023 to 2023Enrolled23ConditionsBehavior, HealthArmsComputer-based Intervention
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Neurology(R) neuroimmunology & neuroinflammation · 2026
    Trial
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  8. Working Memory Training Reduces Cigarette Smoking Among Low-Income Individuals With Elevated Delay Discounting.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Trial
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  10. Working memory training and high magnitude incentives for youth cannabis use: A SMART pilot trial.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
    Trial
  11. Working Memory Training in Alcohol Use Disorder: A Randomized Controlled Trial.Alcoholism, clinical and experimental research · 2019
    Trial
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  15. Trial
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olga RassBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA.
Rebecca L SchachtBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA. Electronic address: rschacht@umbc.edu.
Katherine BuckheitBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA.
Matthew W JohnsonBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA.
Eric C StrainBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA.
Miriam Z MintzerBehavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA.

Funding

HUMAN BEHAVIORAL PHARMACOLOGY OF SUBSTANCE ABUSET32DA007209 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Eric C. Strain, Elise M Weerts · 1985 to 2026
$12.9M
Development of a Prospective Memory Intervention to Reduce Drug Use and HIV RiskR01DA035277 · NIDA · JOHNS HOPKINS UNIVERSITY · PI JOHNSON, MATTHEW WAYNE · 2013 to 2018
$2.0M
Mentoring of Clinical Investigators in Patient Oriented ResearchK24DA023186 · NIDA · JOHNS HOPKINS UNIVERSITY · PI STRAIN, ERIC C. · 2007 to 2016
$1.8M
Effects of Cognitive Training in Methadone Maintenance PatientsR21DA029708 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MINTZER, MIRIAM Z. · 2010 to 2011
$445k
NIDA NIH HHS K23DA023186NIDA NIH HHS K24 DA023186NIDA NIH HHS R01 DA035277NIDA NIH HHS R01DA035277NIDA NIH HHS R21 DA029708NIDA NIH HHS R21DA029708NIDA NIH HHS T32 DA007209NIDA NIH HHS T32DA07209
6 · The paper itself

Abstract

objectiveWorking memory impairment in individuals with chronic opioid dependence can play a major role in cognitive and treatment outcomes. Cognitive training targeting working memory shows promise for improved function in substance use disorders. To date, cognitive training has not been incorporated as an adjunctive treatment for opioid dependence.

methodsMethadone maintenance patients were randomly assigned to experimental (n=28) or active control (n=28) 25-session computerized training and run in parallel. Cognitive and drug use outcomes were assessed before and after training.

resultsParticipants in the experimental condition showed performance improvements on two of four working memory measures, and both groups improved on a third measure of working memory performance. Less frequent drug use was found in the experimental group than in the control group post-training. In contrast to previous findings with stimulant users, no significant effect of working memory training on delay discounting was found using either hypothetical or real rewards. There were no group differences on working memory outcome measures that were dissimilar from the training tasks, suggesting that another mechanism (e.g., increased distress tolerance) may have driven drug use results.

conclusionsWorking memory training improves performance on some measures of working memory in methadone maintenance patients, and may impact drug use outcomes. Working memory training shows promise in patients with substance use disorders; however, further research is needed to understand the mechanisms through which performance is improved and drug use outcomes are impacted.

Indexed as

LearningMemory, Short-TermAdultAttentionDelay DiscountingFemaleHumansMaleMemory, EpisodicMental ProcessesMethadoneMiddle AgedNarcoticsNeuropsychological TestsOpiate Substitution TreatmentOpioid-Related DisordersMethadoneNarcoticsCognitive impairmentDelay discountingMemory trainingMethadone maintenanceWorking memory

Identifiers

PMID26404954
PMCPMC4633307

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.