ArticleScientific reports2015
Microfluidic cytometric analysis of cancer cell transportability and invasiveness.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review.Stem cell research & therapy · 2018Pooled it
- Advances in microfluidic platforms for tumor cell phenotyping: from bench to bedside.Lab on a chip · 2025Review
- Advances in Single-Cell Techniques for Linking Phenotypes to Genotypes.Cancer heterogeneity and plasticity · 2024Article
- Measurement of cell compressibility changes during epithelial-mesenchymal transition based on acoustofluidic microdevice.Biomicrofluidics · 2021Article
- Microfluidic investigation of the effect of graphene oxide on mechanical properties of cell and actin cytoskeleton networks: experimental and theoretical approaches.Scientific reports · 2021Article
- Deformation of an Encapsulated Leukemia HL60 Cell through Sudden Contractions of a Microfluidic Channel.Micromachines · 2021Article
- Inertial cell sorting of microparticle-laden flows: An innovative OpenFOAM-based arbitrary Lagrangian-Eulerian numerical approach.Biomicrofluidics · 2021Article
- An image-based flow cytometric approach to the assessment of the nucleus-to-cytoplasm ratio.PloS one · 2021Article
- Rapid Prototyping of 3D Biochips for Cell Motility Studies Using Two-Photon Polymerization.Frontiers in bioengineering and biotechnology · 2021Article
- Multifunctional microfluidic chip for cancer diagnosis and treatment.Nanotheranostics · 2021Review
- Charge-Based Separation of Micro- and Nanoparticles.Micromachines · 2020Article
- Improving viability of leukemia cells by tailoring shell fluid rheology in constricted microcapillary.Scientific reports · 2020Article
- Fluid shear stress coupled with narrow constrictions induce cell type-dependent morphological and molecular changes in SK-BR-3 and MDA-MB-231 cells.Scientific reports · 2020Article
- Cancer Stem Cell Plasticity - A Deadly Deal.Frontiers in molecular biosciences · 2020Review
- Microfluidic deformability-activated sorting of single particles.Microsystems & nanoengineering · 2020Article
- APOBEC3A is a prominent cytidine deaminase in breast cancer.PLoS genetics · 2019Article
- Modulation of gold nanoparticle mediated radiation dose enhancement through synchronization of breast tumor cell population.The British journal of radiology · 2019Article
- The Extracellular, Cellular, and Nuclear Stiffness, a Trinity in the Cancer Resistome-A Review.Frontiers in oncology · 2019Review
- Multi-sample deformability cytometry of cancer cells.APL bioengineering · 2018Article
- Cytotoxicity of doxrubicin loaded single-walled carbon nanotubes.Molecular biology reports · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The extensive phenotypic and functional heterogeneity of cancer cells plays an important role in tumor progression and therapeutic resistance. Characterizing this heterogeneity and identifying invasive phenotype may provide possibility to improve chemotherapy treatment. By mimicking cancer cell perfusion through circulatory system in metastasis, we develop a unique microfluidic cytometry (MC) platform to separate cancer cells at high throughput, and further derive a physical parameter 'transportability' to characterize the ability to pass through micro-constrictions. The transportability is determined by cell stiffness and cell-surface frictional property, and can be used to probe tumor heterogeneity, discriminate more invasive phenotypes and correlate with biomarker expressions in breast cancer cells. Decreased cell stiffness and cell-surface frictional force leads to an increase in transportability and may be a feature of invasive cancer cells by promoting cell perfusion through narrow spaces in circulatory system. The MC-Chip provides a promising microfluidic platform for studying cell mechanics and transportability could be used as a novel marker for probing tumor heterogeneity and determining invasive phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.