ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2016
Rosacea, Use of Tetracycline, and Risk of Incident Inflammatory Bowel Disease in Women.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Association of rosacea with inflammatory bowel disease: A MOOSE-compliant meta-analysis.Medicine · 2019Pooled it
- The exposomal imprint on rosacea: More than skin deep.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Review
- Gut microbiota signature in a cohort of Chinese patients with rosacea.Biochemistry and biophysics reports · 2025Article
- Do Antibiotics Cause Inflammatory Bowel Disease? A Systematic Review and Meta-Analysis.Visceral medicine · 2025Review
- Detecting potential causal relationship between inflammatory bowel disease and rosacea using bi-directional Mendelian randomization.Scientific reports · 2023Article
- The Relationship Between Rosacea and Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.Dermatology and therapy · 2023Review
- A propensity score matched cohort study identifying an association of acne, but not oral antibiotic or isotretinoin use, with risk of incident inflammatory bowel disease.Journal of the American Academy of Dermatology · 2023Article
- Occurrence of inflammatory bowel disease in patients with chronic inflammatory skin diseases: a cohort study: Classification: Epidemiology.The British journal of dermatology · 2022Article
- Nonantibiotic Properties of Tetracyclines in Rosacea and Their Clinical Implications.The Journal of clinical and aesthetic dermatology · 2021Review
- Safety and Pharmacokinetics of FMX103 (1.5% Minocycline Topical Foam) in Subjects with Moderate-to-Severe Papulopustular Rosacea under Maximum-use Treatment Conditions.The Journal of clinical and aesthetic dermatology · 2021Article
- Immune-mediated diseases and risk of Crohn's disease or ulcerative colitis: a prospective cohort study.Alimentary pharmacology & therapeutics · 2021Article
- Rosacea, Germs, and Bowels: A Review on Gastrointestinal Comorbidities and Gut-Skin Axis of Rosacea.Advances in therapy · 2021Review
- Rosacea and the Microbiome: A Systematic Review.Dermatology and therapy · 2021Review
- Editorial: immune-mediated diseases-are we closer to disease-defining molecular signatures?Alimentary pharmacology & therapeutics · 2021Article
- Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut-Brain-Skin Axis.International journal of molecular sciences · 2020Review
- Open-label Extension Study Evaluating Long-term Safety and Efficacy of FMX103 1.5% Minocycline Topical Foam for the Treatment of Moderate-to-Severe Papulopustular Rosacea.The Journal of clinical and aesthetic dermatology · 2020Article
- Antibiotics in inflammatory bowel diseases: do we know what we're doing?Translational pediatrics · 2019Review
- Assessment of rosacea symptom severity by genome-wide association study and expression analysis highlights immuno-inflammatory and skin pigmentation genes.Human molecular genetics · 2018Article
- Diet and rosacea: the role of dietary change in the management of rosacea.Dermatology practical & conceptual · 2017Review
- Cigarette Smoking and Risk of Incident Rosacea in Women.American journal of epidemiology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsRosacea is an inflammatory skin disease. Case reports have shown rosacea as a comorbidity of inflammatory bowel disease (IBD), but no epidemiologic studies have examined rosacea and risk of subsequent IBD. The association between tetracycline use and risk of IBD was assessed, but this study produced limited findings. We examined the association between rosacea, use of tetracycline, and risk of incident Crohn's disease (CD) and ulcerative colitis (UC).
methodsWe analyzed data from 96,314 participants in the Nurses' Health Study II (1991-2011). Information on IBD was confirmed by medical review. Participants were asked in 2005 about their lifetime histories of clinician-diagnosed rosacea and year of diagnosis. Information on ever use of tetracycline was collected in 1993.
resultsDuring 1,856,587 person-years (1991-2011), we identified 149 cases of CD and 215 cases of UC. Rosacea was not associated with risk of UC. In contrast, rosacea was significantly associated with increased risk of subsequent CD (hazard ratio [HR], 2.20; 95% confidence interval [CI], 1.15-4.18), which appeared particularly stronger for a longer duration after a diagnosis of rosacea (Ptrend = .01). Tetracycline use was associated with increased risk of CD (HR, 1.56; 95% CI, 1.09-2.24) and UC (HR, 1.34; 95% CI, 1.00-1.80); there was a trend toward increased risk with increased duration of use (both Ptrend < .05) (1993-2011).
conclusionsOn the basis of an analysis of data from the Nurses' Health Study II, ever use of tetracycline at baseline is associated with an increased risk of CD and UC. Personal history of rosacea is associated with an increased risk of only CD.
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