ArticleLasers in medical science2015
Photodynamic inactivation of a multispecies biofilm using Photodithazine(®) and LED light after one and three successive applications.
Article in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Photodithazine-Mediated Antimicrobial Photodynamic Therapy: A Systematic Review of Efficacy and Applications.International journal of molecular sciences · 2025Pooled it
- Effects of antimicrobial photodynamic therapy with zinc oxide and toluidine blue on Streptococcus mutans accumulation in polymethyl methacrylate resin used in orthodontic appliances.Lasers in medical science · 2025Article
- MixedJournal of fungi (Basel, Switzerland) · 2025Article
- Photodynamic Effects of Topical Photosensitizer, Photodithazine Using Micro-LED for Acne Bacteria Induced Inflammation.Annals of dermatology · 2024Article
- Adhesion of biofilm, surface characteristics, and mechanical properties of antimicrobial denture base resin.The journal of advanced prosthodontics · 2023Article
- In it together: Candida-bacterial oral biofilms and therapeutic strategies.Environmental microbiology reports · 2022Review
- Efficiency of Antimicrobial Photodynamic Therapy with PhotodithazineAntibiotics (Basel, Switzerland) · 2021Article
- Avoiding ventilator-associated pneumonia: Curcumin-functionalized endotracheal tube and photodynamic action.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Management ofJournal of clinical medicine · 2020Review
- Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study.Scientific reports · 2019Article
- Antimicrobial Photodynamic Therapy in Combination with Nystatin in the Treatment of Experimental Oral Candidiasis Induced byPharmaceuticals (Basel, Switzerland) · 2019Article
- Could a chelant improve the effect of curcumin-mediated photodynamic antimicrobial chemotherapy against dental intact biofilms?Lasers in medical science · 2019Article
- Twice-daily red and blue light treatment for Candida albicans biofilm matrix development control.Lasers in medical science · 2019Article
- Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention.Heliyon · 2018Review
- Curcumin-mediated anti-microbial photodynamic therapy against Candida dubliniensis biofilms.Lasers in medical science · 2018Article
- Virulence factors of fluconazole-susceptible and fluconazole-resistant Candida albicans after antimicrobial photodynamic therapy.Lasers in medical science · 2017Article
- Repeated applications of photodynamic therapy on Candida glabrata biofilms formed in acrylic resin polymerized.Lasers in medical science · 2017Article
- Photodynamic inactivation of pathogenic species Pseudomonas aeruginosa and Candida albicans with lutetium (III) acetate phthalocyanines and specific light irradiation.Lasers in medical science · 2016Article
- Photodynamic inactivation of a multispecies biofilm using curcumin and LED light.Lasers in medical science · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this investigation, the effectiveness of successive applications of antimicrobial photodynamic inactivation (API) mediated by Photodithazine(®) (PDZ) and LED light was evaluated against a multispecies biofilm formed by Candida albicans, Candida glabrata, and Streptococcus mutans on denture base acrylic resin. Standard cell suspensions (bacteria and yeast) were inoculated on acrylic resin samples, and the biofilm was grown for 48 h (37 °C/75 rpm). API was performed by the administration of PDZ (175 and 200 mg/L) and exposure to 37.5 J/cm(2) of LED light (660 nm). Additional samples were treated with PDZ or LED light only. Untreated control samples were not submitted to light or PDZ. The conditions described were applied once or in three consecutive applications for all groups. Cell viability was determined by colony counts (CFU/mL), metabolic activity, total biomass, and confocal laser scanning microscopy (CLSM). Data were analyzed by a nonparametric two-way ANOVA and Tukey tests (α = 0.05). The results obtained demonstrated a significant effect (p < 0.05) of number of applications and treatment groups for CFU/mL, and S. mutans showed the highest susceptibility to API. The metabolic activity of the multispecies biofilm was significantly reduced (p < 0.05) after API for both numbers of applications, which were also significantly different (p < 0.05) between them. The total biomass of the biofilm was significantly different (p < 0.05) only between groups submitted to one and three API applications. CLSM showed a visual increase of dead cells after API. API-mediated PDZ was effective in reducing the cell viability of multispecies biofilm. Three consecutive applications of API were more effective for reducing the cell viability and the total biomass of multispecies biofilm.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.