Evidence map›Paper›PMID 26404726›Full record

ReviewCurrent neurology and neuroscience reports2015

Seizure Prediction: Science Fiction or Soon to Become Reality?

Dean R Freestone, Philippa J Karoly, Andre D H Peterson, Levin Kuhlmann, Alan Lai, Farhad Goodarzy, Mark J Cook

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Utilizing Causal Network Markers to Identify Tipping Points ahead of Critical Transition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Article
  3. Article
  4. Neurosurgery and the Brain-Computer Interface.Advances in experimental medicine and biology · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Dynamic training of a novelty classifier algorithm for real-time detection of early seizure onset.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Seizure prediction - ready for a new era.Nature reviews. Neurology · 2018
    Review
  18. Seizure pathways: A model-based investigation.PLoS computational biology · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dean R FreestoneDepartment of Medicine, St. Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy, VIC, Australia, 3065. deanrf@unimelb.edu.au.
Philippa J KarolyDepartment of Medicine, St. Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy, VIC, Australia, 3065.
Andre D H PetersonDepartment of Medicine, St. Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy, VIC, Australia, 3065.
Levin KuhlmannDepartment of Electrical and Electronic Engineering, The University of Melbourne, Parkville, VIC, Australia, 3000.
Alan LaiDepartment of Electrical and Electronic Engineering, The University of Melbourne, Parkville, VIC, Australia, 3000.
Farhad GoodarzyDepartment of Electrical and Electronic Engineering, The University of Melbourne, Parkville, VIC, Australia, 3000.
Mark J CookDepartment of Medicine, St. Vincent's Hospital Melbourne, The University of Melbourne, Fitzroy, VIC, Australia, 3065. markcook@unimelb.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review highlights recent developments in the field of epileptic seizure prediction. We argue that seizure prediction is possible; however, most previous attempts have used data with an insufficient amount of information to solve the problem. The review discusses four methods for gaining more information above standard clinical electrophysiological recordings. We first discuss developments in obtaining long-term data that enables better characterisation of signal features and trends. Then, we discuss the usage of electrical stimulation to probe neural circuits to obtain robust information regarding excitability. Following this, we present a review of developments in high-resolution micro-electrode technologies that enable neuroimaging across spatial scales. Finally, we present recent results from data-driven model-based analyses, which enable imaging of seizure generating mechanisms from clinical electrophysiological measurements. It is foreseeable that the field of seizure prediction will shift focus to a more probabilistic forecasting approach leading to improvements in the quality of life for the millions of people who suffer uncontrolled seizures. However, a missing piece of the puzzle is devices to acquire long-term high-quality data. When this void is filled, seizure prediction will become a reality.

Indexed as

AnimalsElectrodesElectroencephalographyHumansNeurosciencesQuality of LifeSeizuresActive EEGAmbulatory EEGComputational neuroscienceElectrophysiologyEpileptic seizure predictionMicro-electrodeReview

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.