ReviewNature neuroscience2015
Stress effects on the neural substrates of motivated behavior.
Review in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed.
- Cellular and molecular coding of habit-driven behavior in the dorsal raphe nucleus.bioRxiv : the preprint server for biology · 2026Article
- Onset of workplace bullying and violence and changes in health-related behaviors: a multi-cohort study.Scandinavian journal of work, environment & health · 2026Article
- Behavioral Domain-Specific Effects of Positive Modulation of α5 and α6 GABAPharmacology research & perspectives · 2026Article
- Demonstrating the ability of GABAergic cells in the zona incerta to modulate motivation.bioRxiv : the preprint server for biology · 2026Article
- GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice.Journal of neuroendocrinology · 2025Article
- Article
- An inverted U-shaped relationship between chronic stress and the motivation to expend effort for reward.Neurobiology of stress · 2025Article
- Translating stress systems: corticotropin releasing factor, its receptors, and the dopamine system in nonhuman primate models.Genomic psychiatry : advancing science from genes to society · 2025Article
- Adapting new norms: A mixed-method study exploring mental well-being challenges in dental technology education.PloS one · 2025Article
- Case Report: Prolonged DAWS in an RLS patient under severe relational stress.Frontiers in human neuroscience · 2025Article
- Chronic Pain and Substance Use Disorders: A Brief Narrative Review of Genetic, Neurobiological, and Environmental Contributions to Comorbidity.Journal of psychiatry and brain science · 2025Article
- Association between sleep disorder and anhedonia in adolescence with major depressive disorder: the mediating effect of stress.BMC psychiatry · 2024Article
- Neural and immune interactions linking early life stress and anhedonia.Brain, behavior, & immunity - health · 2024Article
- Effects of acute stress on reward processing: A comprehensive meta-analysis of rodent and human studies.Neurobiology of stress · 2024Review
- Dynamic Ecosystem Adaptation through Allostasis (DEA-A) Model: Conceptual Presentation of an Integrative Theoretical Framework for Global Health Change.International journal of environmental research and public health · 2024Article
- Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex.Scientific reports · 2024Article
- Neural sensitivity following stress predicts anhedonia symptoms: a 2-year multi-wave, longitudinal study.Translational psychiatry · 2024Article
- A stress-sensitive frontostriatal circuit supporting effortful reward-seeking behavior.Neuron · 2024Article
- Hypothalamic CRF neurons facilitate brain reward function.Current biology : CB · 2024Article
- Social defeat stress induces an anxiety-like outcome in male prairie voles (Oxford open neuroscience · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Exposure to stress has profound, but complex, actions on motivated behavior and decision-making. These effects are central to core symptoms of a number of psychiatric disorders that are precipitated or augmented by stress, such as depressive disorders and substance use disorders. Studying the neural substrates of stress's effects on motivation has revealed that stress affects multiple targets on circuits throughout the brain using diverse molecular signaling processes. Moreover, stress does not have unitary effects on motivated behavior, but differences in the intensity, duration, intermittency, controllability and nature of the stressor produce qualitatively and quantitatively different behavioral endpoints. Unsurprisingly, the results of neuroscientific investigations into stress and motivation often open more questions than they resolve. Here we discuss contemporary results pertaining to the neural mechanisms by which stress alters motivation, identify points of contention and highlight integrative areas for continuing research into these multifaceted complexities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.