ArticleTrends in endocrinology and metabolism: TEM2015
Mitochondria Cripple without Krüppel.
Article in Trends in endocrinology and metabolism: TEM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Natural products modulate renal metabolic reprogramming in diabetic kidney disease.Journal of translational internal medicine · 2026Article
- KLF4 regulates skeletal muscle development and regeneration by directly targeting P57 and Myomixer.Cell death & disease · 2023Article
- Bone Marrow Mesenchymal Stem Cell-Derived Exosomal KLF4 Alleviated Ischemic Stroke Through Inhibiting N6-Methyladenosine Modification Level of Drp1 by Targeting lncRNA-ZFAS1.Molecular neurobiology · 2023Article
- Klf4-Sirt3/Pparα-Lcad pathway contributes to high phosphate-induced lipid degradation.Cell communication and signaling : CCS · 2023Article
- PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- The Role of Axon Transport in Neuroprotection and Regeneration.Developmental neurobiology · 2018Review
- Krüppel-like factor 4 (KLF4) induces mitochondrial fusion and increases spare respiratory capacity of human glioblastoma cells.The Journal of biological chemistry · 2018Article
- Kruppel-Like Factor 4 (KLF4) and its Regulation on Mitochondrial Homeostasis.Journal of stem cell research & therapy · 2018Article
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Authors and funding
2 authors.
Funding
Abstract
Proper mitochondrial biogenesis and removal is crucial in maintaining a healthy heart. Liao et al now show key roles for cardiac KLF4 in mitochondrial homeostasis via its interaction with the ERR/PGC-1 module, and mitochondrial clearance via regulation of mitophagy. Disruption of KLF4 leads to profoundly injured mitochondria and cardiac failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.