ArticlePediatric nephrology (Berlin, Germany)2016
Insignificant impact of VUR on the progression of CKD in children with CAKUT.
Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 21 citations in OpenAlex.
- Clinical and Molecular characteristics of kidney and urinary tract congenital anomalies in a cohort of Egyptian patients using whole-exome sequencing.Molecular biology reports · 2026Article
- Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies.Pediatric nephrology (Berlin, Germany) · 2022Review
- Decreased Identification of Vesicoureteral Reflux: A Cautionary Tale.Frontiers in pediatrics · 2017Article
- Primary Vesicoureteral reflux and chronic kidney disease in pediatric population. What we have learnt?International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
14 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVesicoureteral reflux (VUR) is associated with an increased risk of kidney disorders. It is unclear whether VUR is associated with progression from chronic kidney disease (CKD) to end-stage kidney disease (ESKD) in children with congenital anomalies of the kidney and urinary tract (CAKUT).
methodsWe conducted a 3-year follow-up survey of a cohort of 447 children with CKD (stage 3-5). Rates of and risk factors for progression to ESKD were determined using the Kaplan-Meier method and Cox regression respectively.
resultsCongenital anomaly of the kidney and urinary tract was the primary etiology in 278 out of 447 children; 118 (42.4 %) had a history of VUR at the start of the cohort study. There were significantly more boys than girls with VUR, whereas the proportions were similar in children without VUR. The types of urinary anomalies/complications of the two groups were significantly different. Three-year renal survival rates of the groups were not significantly different, irrespective of CKD stage. Age < 2 years and age after puberty, stage 4 or 5 CKD, and heavy proteinuria, but not history of VUR, were significantly associated with progression to ESKD.
conclusionsHistory of VUR at the start of follow-up was not associated with the progression of stage 3-5 CKD in children with CAKUT.
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