Evidence map›Paper›PMID 26404420›Full record

Trial reportThe American journal of psychiatry2015

Preventing Onset of Anxiety Disorders in Offspring of Anxious Parents: A Randomized Controlled Trial of a Family-Based Intervention.

Golda S Ginsburg, Kelly L Drake, Jenn-Yun Tein, Rebekah Teetsel, Mark A Riddle

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 6 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 6 syntheses or guidelines pooled it, 163 citations in OpenAlex.

  1. Pooled it
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  6. Brief, Non-Pharmacological, Interventions for Pediatric Anxiety: Meta-Analysis and Evidence Base Status.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Pooled it
  7. Trial
  8. Evaluating a program to prevent anxiety in children of anxious parents: a randomized controlled trial.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Trial
  9. Trial
  10. Child Anxiety Prevention Study: Impact on Functional Outcomes.Child psychiatry and human development · 2017
    Trial
  11. Article
  12. Managing anxiety-related disorders from pregnancy to parenthood.Archives of gynecology and obstetrics · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Golda S GinsburgFrom the Department of Psychiatry, School of Medicine, University of Connecticut Health Center, West Hartford; the Department of Psychiatry and Behavioral Sciences and the Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore; and the Department of Psychology, Arizona State University, Tempe.
Kelly L DrakeFrom the Department of Psychiatry, School of Medicine, University of Connecticut Health Center, West Hartford; the Department of Psychiatry and Behavioral Sciences and the Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore; and the Department of Psychology, Arizona State University, Tempe.
Jenn-Yun TeinFrom the Department of Psychiatry, School of Medicine, University of Connecticut Health Center, West Hartford; the Department of Psychiatry and Behavioral Sciences and the Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore; and the Department of Psychology, Arizona State University, Tempe.
Rebekah TeetselFrom the Department of Psychiatry, School of Medicine, University of Connecticut Health Center, West Hartford; the Department of Psychiatry and Behavioral Sciences and the Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore; and the Department of Psychology, Arizona State University, Tempe.
Mark A RiddleFrom the Department of Psychiatry, School of Medicine, University of Connecticut Health Center, West Hartford; the Department of Psychiatry and Behavioral Sciences and the Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore; and the Department of Psychology, Arizona State University, Tempe.
Johns Hopkins University · USArizona State University · US

Funding

Family Based Prevention of Child AnxietyR01MH077312 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GINSBURG, GOLDA SUSAN · 2008 to 2012
$2.5M
Integrating Biological Markers into Clinical ResearchK24MH096760 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GINSBURG, GOLDA SUSAN · 2013 to 2016
$653k
NIMH NIH HHS K24 MH096760NIMH NIH HHS R01 MH077312
6 · The paper itself

Abstract

objectiveThe authors examined the efficacy of a family-based intervention to prevent the onset of anxiety disorders in offspring of anxious parents.

methodParticipants were 136 families with a parent meeting DSM-IV criteria for an anxiety disorder and one child 6-13 years of age without an anxiety disorder. Families were randomly assigned to the family-based intervention (N=70) or to an information-monitoring control condition (N=66). All families were expected to complete assessments, administered by blind interviewers, at baseline, at the end of the intervention (or 8 weeks after randomization) and at 6- and 12-month follow-ups. Onset of any anxiety disorder and anxiety symptom severity (assessed using the Anxiety Disorders Interview Schedule for Children) at 12 months were the primary and secondary outcome measures, respectively.

resultsThe incidence of child anxiety disorders was 31% in the control group and 5% in the intervention group (odds ratio=8.54, 95% CI=2.27, 32.06). At the 1-year follow-up, youths in the control group also had higher anxiety symptoms ratings than those in the intervention group. Effect sizes were medium to large (0.81 at 6 months and 0.57 at 12 months for anxiety symptoms), and the number needed to treat was 3.9 at 12 months. Significant moderators included baseline levels of child anxiety; significant mediators were parental distress and modeling of anxiety. Child maladaptive cognitions and parental anxiety did not mediate outcomes.

conclusionsA brief psychosocial prevention program holds promise for reducing the 1-year incidence of anxiety disorders among offspring of anxious parents.

Indexed as

Family TherapyAdolescentAnxiety DisordersChildChild of Impaired ParentsFemaleHumansMaleTreatment Outcome

Identifiers

PMID26404420
PMCPMC6013063
OpenAlexW2097013960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.