ArticleInternational journal of environmental research and public health2015
Associations between Urinary Excretion of Cadmium and Renal Biomarkers in Nonsmoking Females: A Cross-Sectional Study in Rural Areas of South China.
Article in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The Protective Potential ofInternational journal of molecular sciences · 2023Article
- Current Levels of Environmental Exposure to Cadmium in Industrialized Countries as a Risk Factor for Kidney Damage in the General Population: A Comprehensive Review of Available Data.International journal of molecular sciences · 2023Review
- Revisiting the Role of NAG across the Continuum of Kidney Disease.Bioengineering (Basel, Switzerland) · 2023Review
- Dose-Response Analysis of the Tubular and Glomerular Effects of Chronic Exposure to Environmental Cadmium.International journal of environmental research and public health · 2022Article
- Review
- Sex-specific differences in early renal impairment associated with arsenic, lead, and cadmium exposure among young adults in Taiwan.Environmental science and pollution research international · 2022Article
- Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health.Biomarker insights · 2022Review
- Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-κB pathway in vitro and in vivo.Archives of toxicology · 2021Article
- Association Between Cadmium Exposure and Liver Function in Adults in the United States: A Cross-sectional Study.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2021Article
- The Effect of Cadmium on GFR Is Clarified by Normalization of Excretion Rates to Creatinine Clearance.International journal of molecular sciences · 2021Article
- Article
- Review
- An assessment of sensitivity biomarkers for urinary cadmium burden.BMC nephrology · 2020Article
- Article
- Environmental and Occupational Exposures in Kidney Disease.Seminars in nephrology · 2019Review
- In situ, dual-mode monitoring of organ-on-a-chip with smartphone-based fluorescence microscope.Biosensors & bioelectronics · 2016Article
- A longitudinal study on urinary cadmium and renal tubular protein excretion of nickel-cadmium battery workers after cessation of cadmium exposure.International archives of occupational and environmental health · 2016Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to systematically evaluate the relationship between urinary excretion of cadmium (U-Cd) and biomarkers of renal dysfunction.
methodsOne hundred eighty five non-smoking female farmers (aged from 44 to 71 years) were recruited from two rural areas with different cadmium levels of exposure in southern China. Morning spot urine samples were collected for detecting U-Cd, urinary creatinine (U-cre), β₂-microglobulin (β₂-MG), α₁-microglobulin (α₁-MG), metallothionein (MT), retinol binding protein (RBP), albumin (AB), N-acetyl-β-D-glucosaminidase (NAG), alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGT) and kidney injury molecule-1 (KIM-1). Spearman's rank correlation was carried out to assess pairwise bivariate associations between continuous variables. Three different models of multiple linear regression (the cre-corrected, un-corrected and cre-adjusted model) were used to model the dose-response relationships between U-Cd and nine urine markers.
resultsSpearman's rank correlation showed that NAG, ALP, RBP, β₂-MG and MT were significantly associated with U-Cd for both cre-corrected and observed data. Generally, NAG correlated best with U-Cd among the nine biomarkers studied, followed by ALP and MT. In the un-corrected model and cre-adjusted model, the regression coefficients and R² of nine biomarkers were larger than the corresponding values in the cre-corrected model, indicating that the use of observed data was better for investigating the relationship between biomarkers and U-Cd than cre-corrected data.
conclusionsOur results suggest that NAG, MT and ALP in urine were better biomarkers for long-term environmental cadmium exposure assessment among the nine biomarkers studied. Further, data without normalization with creatinine show better relationships between cadmium exposure and renal dysfunction.
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