ArticleScientific reports2015
Three-dimensional non-destructive soft-tissue visualization with X-ray staining micro-tomography.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
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- Quantitative Stain Mapping in X-Ray Virtual Histology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Detailed microCT imaging protocol for ex vivo rat stomachs with comparative analysis.Scientific reports · 2025Article
- Near-Freezing-Temperature Golgi Neuronal Staining for X-ray Imaging of Human Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Unveiling Another Dimension: Advanced Visualization of Cancer Invasion and Metastasis via Micro-CT Imaging.Cancers · 2025Article
- The use of ethanol as contrast enhancer in synchrotron X-ray phase-contrast imaging leads to heterogeneous myocardial tissue shrinkage: a case report.Journal of synchrotron radiation · 2025Article
- Micro-Computed Tomography as a complementary tool for histopathological diagnosis of oral soft tissue lesions - Proof of concept.PloS one · 2025Article
- Integrating X-ray phase-contrast imaging and histology for comparative evaluation of breast tissue malignancies in virtual histology analysis.Scientific reports · 2024Article
- Optimal Agents for Visualizing Collagen Tissue Microarchitecture Using Contrast-Enhanced MicroCT.Pharmaceuticals (Basel, Switzerland) · 2023Review
- A defined road to tracheal reconstruction: laser structuring and cell support for rapid clinic translation.Stem cell research & therapy · 2022Article
- Synchrotron X-ray biosample imaging: opportunities and challenges.Biophysical reviews · 2022Article
- Three-dimensional label-free histological imaging of whole organs by microtomy-assisted autofluorescence tomography.iScience · 2022Article
- Virtual reality for 3D histology: multi-scale visualization of organs with interactive feature exploration.BMC cancer · 2021Article
- Three-dimensional reconstruction of testis cords/seminiferous tubules.Reproductive medicine and biology · 2021Review
- Development of Vancomycin Delivery Systems Based on Autologous 3D Platelet-Rich Fibrin Matrices for Bone Tissue Engineering.Biomedicines · 2021Article
- Additive Manufacturing of Multi-Scale Porous Soft Tissue Implants That Encourage Vascularization and Tissue Ingrowth.Advanced healthcare materials · 2021Article
- 3D-Non-destructive Imaging through Heavy-Metal Eosin Salt Contrast Agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Iodine staining outperforms phosphotungstic acid in high-resolution micro-CT scanning of post-natal mice cardiac structures.Journal of medical imaging (Bellingham, Wash.) · 2021Article
- A versatile technique for high-resolution three-dimensional imaging of human arterial segments using microcomputed tomography.JVS-vascular science · 2021Article
- Assaying three-dimensional cellular architecture using X-ray tomographic and correlated imaging approaches.The Journal of biological chemistry · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low inherent contrast in soft tissues has been limiting the use of X-ray absorption micro-computed tomography (micro-CT) to access high-resolution structural information of animal organs. The staining agents used in micro-CT to improve the contrast fail in providing high-quality images of whole organs of animals due to diffusion problems of the staining agent into the sample. We demonstrate a staining protocol that incorporates a biochemical conditioning step prior to exposure to the staining agent that succeeds in overcoming the diffusion problems, thus quickly providing high-quality micro-CT images of whole organs of mammals. Besides of yielding non-distorted three-dimensional information at the same spatial resolution accessible in histological sections, micro-CT images of whole organs stained by our method enable easy screening of slices along any direction of the volume thus demonstrating new possibilities of structural analysis in biomedical science.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.