ArticleBMC microbiology2015
In vitro evaluation of novel antimicrobial coatings for surgical sutures using octenidine.
Article in BMC microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 60 citations in OpenAlex.
- Drug-Eluting Sutures by Hot-Melt Extrusion: Current Trends and Future Potentials.Materials (Basel, Switzerland) · 2023Review
- Enhancing Dental Applications: A Novel Approach for Incorporating Bioactive Substances into Textile Threads.Pharmaceutics · 2023Article
- [Surgical suture material-fundamentals].Operative Orthopadie und Traumatologie · 2023Article
- Potential application of menadione for antimicrobial coating of surgical sutures.Biotechnology notes (Amsterdam, Netherlands) · 2023Article
- Synthesis of a novel monofilament bioabsorbable suture for biomedical applications.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Applications of Electrospun Drug-Eluting Nanofibers in Wound Healing: Current and Future Perspectives.Polymers · 2022Review
- Wound Antiseptics and European Guidelines for Antiseptic Application in Wound Treatment.Pharmaceuticals (Basel, Switzerland) · 2021Review
- In vitro evaluation of antibacterial efficacy of vancomycin-loaded suture tapes and cerclage wires.Journal of materials science. Materials in medicine · 2021Article
- Nonfouling textiles with tunable antimicrobial activity based on a zwitterionic polyamine finish.RSC advances · 2019Article
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- Preventing Surgical Site Infections Using a Natural, Biodegradable, Antibacterial Coating on Surgical Sutures.Molecules (Basel, Switzerland) · 2017Article
- Application of Materials as Medical Devices with Localized Drug Delivery Capabilities for Enhanced Wound Repair.Progress in materials science · 2017Article
- [Local antibiotic therapy].Der Unfallchirurg · 2017Review
- Effect of Hyaluronic Acid Added to Suture Material and its Relationship with Bacterial Colonization: AnJournal of International Society of Preventive & Community DentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSutures colonized by bacteria represent a challenge in surgery due to their potential to cause surgical site infections. In order to reduce these type of infections antimicrobially coated surgical sutures are currently under development. In this study, we investigated the antimicrobial drug octenidine as a coating agent for surgical sutures. To achieve high antimicrobial efficacy and required biocompatibility for medical devices, we focused on optimizing octenidine coatings based on fatty acids. For this purpose, antimicrobial sutures were prepared with either octenidine-laurate or octenidine-palmitate at 11, 22, and 33 μg/cm drug concentration normalized per length of sutures. Octenidine containing sutures were compared to the commercial triclosan-coated suture Vicryl® Plus. The release of octenidine into aqueous solution was analyzed and long-term antimicrobial efficacy was assessed via agar diffusion tests using Staphylococcus aureus. For determining biocompatibility, cytotoxicity assays (WST-1) were performed using L-929 mouse fibroblasts.
resultsIn a 7 days elution experiment, octenidine-palmitate coated sutures demonstrated much slower drug release (11 μg/cm: 7%; 22 μg/cm: 5%; 33 μg/cm: 33%) than octenidine-laurate sutures (11 μg/cm: 82%; 22 μg/cm: 88%; 33 μg/cm: 87%). Furthermore sutures at 11 μg/cm drug content were associated with acceptable cytotoxicity according to ISO 10993-5 standard and showed, similar to Vicryl® Plus, relevant efficacy to inhibit surrounding bacterial growth for up to 9 days.
conclusionsOctenidine coated sutures with a concentration of 11 μg/cm revealed high antimicrobial efficacy and biocompatibility. Due to their delayed release, palmitate carriers should be preferred. Such coatings are candidates for clinical testing in regard to their safety and efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.