Evidence map›Paper›PMID 26404018›Full record

Trial reportBrain imaging and behavior2016

Go/No Go task performance predicts cortical thickness in the caudal inferior frontal gyrus in young adults with and without ADHD.

Erik Newman, Terry L Jernigan, Krista M Lisdahl, Leanne Tamm, Susan F Tapert, Steven G Potkin, Daniel Mathalon, Brooke Molina, James Bjork, F Xavier Castellanos and 7 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain imaging and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 1 country.

Erik NewmanCenter for Human Development, University of California, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA. enewman@ucsd.edu.
Terry L JerniganCenter for Human Development, University of California, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA.
Krista M LisdahlDepartment of Psychology, University of Wisconsin Milwaukee, Milwaukee, WI, USA.
Leanne TammDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Susan F TapertDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Steven G PotkinDepartment of Psychiatry, University of California, Irvine, Irvine, CA, USA.
Daniel MathalonDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Brooke MolinaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
James BjorkDepartment of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
F Xavier CastellanosDepartment of Child and Adolescent Psychiatry, Child Study Center at NYU Langone Medical Center, New York, NY, USA.
James SwansonThe Child Development Center, University of California, Irvine, Irvine, CA, USA.
Joshua M KupermanDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Hauke BartschMultimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
Chi-Hua ChenDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Anders M DaleDepartment of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.
Jeffery N EpsteinDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
MTA Neuroimaging Group
University of California, San Diego · USCincinnati Children's Hospital Medical Center · USUniversity of California, Irvine · USNYU Langone Health · USUniversity of California, San Francisco · USUniversity of Pittsburgh · USUniversity of Wisconsin–Milwaukee · USVirginia Commonwealth University · US

Funding

Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
Mapping Individual Cognitive Differences to Neural Variance and School ReadinessR01HD061414 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JERNIGAN, TERRY L. · 2010 to 2014
$3.3M
IDEAA: UWM SiteR01DA030354 · NIDA · UNIVERSITY OF WISCONSIN MILWAUKEE · PI LISDAHL, KRISTA MAURINE · 2011 to 2017
$2.7M
Neurobehavioral Contributors to Math Failure: A Reward-Based Learning FrameworkR24HD075489 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JERNIGAN, TERRY L. · 2012 to 2015
$2.2M
Pathways to adult substance use and abuse from childhood ADHD in the MTAR01DA039881 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2015 to 2018
$1.1M
NICHD NIH HHS R01 HD061414NICHD NIH HHS R24 HD075489NIDA NIH HHS HHSN271200800009CNIDA NIH HHS R01 DA030354NIDA NIH HHS R01 DA039881NIDA NIH HHS RC2 DA029475
6 · The paper itself

Abstract

Response inhibition deficits are widely believed to be at the core of Attention-Deficit Hyperactivity Disorder (ADHD). Several studies have examined neural architectural correlates of ADHD, but research directly examining structural correlates of response inhibition is lacking. Here we examine the relationship between response inhibition as measured by a Go/No Go task, and cortical surface area and thickness of the caudal inferior frontal gyrus (cIFG), a region implicated in functional imaging studies of response inhibition, in a sample of 114 young adults with and without ADHD diagnosed initially during childhood. We used multiple linear regression models to test the hypothesis that Go/No Go performance would be associated with cIFG surface area or thickness. Results showed that poorer Go/No Go performance was associated with thicker cIFG cortex, and this effect was not mediated by ADHD status or history of substance use. However, independent of Go/No Go performance, persistence of ADHD symptoms and more frequent cannabis use were associated with thinner cIFG. Go/No Go performance was not associated with cortical surface area. The association between poor inhibitory functioning and thicker cIFG suggests that maturation of this region may differ in low performing participants. An independent association of persistent ADHD symptoms and frequent cannabis use with thinner cIFG cortex suggests that distinct neural mechanisms within this region may play a role in inhibitory function, broader ADHD symptomatology, and cannabis use. These results contribute to Research Domain Criteria (RDoC) by revealing novel associations between neural architectural phenotypes and basic neurobehavioral processes measured dimensionally.

Indexed as

Inhibition, PsychologicalAdultAlcohol-Related DisordersAttention Deficit Disorder with HyperactivityExecutive FunctionFemaleFollow-Up StudiesFrontal LobeHumansImage Processing, Computer-AssistedLongitudinal StudiesMagnetic Resonance ImagingMaleMarijuana AbuseNeuropsychological TestsOrgan SizeADHD persistenceAlcohol useCannabis useCortical surface areaMRIResponse inhibition

Identifiers

PMID26404018
PMCPMC4808505
OpenAlexW1912403812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.