Evidence map›Paper›PMID 26403814›Full record

ArticleInternational journal of epidemiology2016

Long-term status and change of body fat distribution, and risk of colorectal cancer: a prospective cohort study.

Mingyang Song, Frank B Hu, Donna Spiegelman, Andrew T Chan, Kana Wu, Shuji Ogino, Charles S Fuchs, Walter C Willett, Edward L Giovannucci

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 7 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 7 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mingyang SongDepartment of Nutrition, Department of Epidemiology, Harvard T.H. ChanSchool of Public Health, Boston, MA, USA, msong@hsph.harvard.edu.
Frank B HuDepartment of Nutrition, Department of Epidemiology, Harvard T.H. ChanSchool of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.
Donna SpiegelmanDepartment of Nutrition, Department of Epidemiology, Harvard T.H. ChanSchool of Public Health, Boston, MA, USA, Department of Biostatistics, Department of Global Health and Population, Harvard T.H. ChanSchool of Public Health, Boston, MA, USA.
Andrew T ChanChanning Division of Network Medicine, Harvard Medical School, Boston, MA, USA, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
Kana WuDepartment of Nutrition.
Shuji OginoDepartment of Epidemiology, Harvard T.H. ChanSchool of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA and Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Charles S FuchsChanning Division of Network Medicine, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA and.
Walter C WillettDepartment of Nutrition, Department of Epidemiology, Harvard T.H. ChanSchool of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.
Edward L GiovannucciDepartment of Nutrition, Department of Epidemiology, Harvard T.H. ChanSchool of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA.
Harvard University · USDana-Farber Cancer Institute · USMassachusetts General Hospital · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIOVANNUCCI, EDWARD · 2000 to 2019
$77.8M
Tissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI EL-BARDEESY, NABEEL, SELLERS, WILLIAM R · 2007 to 2023
$33.2M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
Sleep Duration, Childhood Energy Balance, and Insulin Resistance in AdolescenceU54CA155626 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI MEYERHARDT, JEFFREY A · 2011 to 2015
$9.6M
Inflammation and Colorectal NeoplasiaR01CA137178 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T · 2009 to 2019
$6.5M
Accelerating Transdisciplinary Epidemiology of Colorectal CancerR35CA197735 · NCI · DANA-FARBER CANCER INST · PI OGINO, SHUJI · 2015 to 2021
$6.0M
Epigenetic Events and Colorectal Cancer EpidemiologyR01CA151993 · NCI · DANA-FARBER CANCER INST · PI OGINO, SHUJI · 2010 to 2014
$2.6M
Mentored Patient-Oriented Research in Digestive DiseasesK24DK098311 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T · 2013 to 2017
$930k
Lifestyle, genetics and colonoscopy for colorectal cancer preventionK07CA190673 · NCI · DANA-FARBER CANCER INST · PI NISHIHARA, REIKO · 2014 to 2018
$609k
NCI NIH HHS K07 CA190673NCI NIH HHS P01 CA087969NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA151993NCI NIH HHS R35 CA197735NCI NIH HHS U54 CA155626NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NIDDK NIH HHS K24 DK098311
6 · The paper itself

Abstract

backgroundAlthough obesity has been linked to an increased risk of colorectal cancer (CRC), the risk associated with long-term status or change of body fat distribution has not been fully elucidated.

methodsUsing repeated anthropometric assessments in the Nurses' Health Study and Health Professionals Follow-up Study, we prospectively investigated cumulative average waist circumference, hip circumference and waist-to-hip ratio, as well as their 10-year changes over adulthood, in relation to CRC risk over 23-24 years of follow-up. Cox proportional hazards models were used to calculate the hazard ratio (HR) and 95% confidence interval (CI).

resultsHigh waist circumference, hip circumference and waist-to-hip ratio were all associated with a higher CRC risk in men, even after adjusting for body mass index. The association was attenuated to null in women after adjusting for body mass index. Ten-year gain of waist circumference was positively associated with CRC risk in men (P for trend = 0.03), but not in women (P for trend = 0.34).Compared with men maintaining their waist circumference, those gaining waist circumference by ≥ 10 cm were at a higher risk of CRC, with a multivariable-adjusted HR of 1.59 (95% CI, 1.01-2.49). This association appeared to be independent of weight change.

conclusionsAbdominal adiposity, independent of overall obesity, is associated with an increased CRC risk in men but not in women. Our findings also provide the first prospective evidence that waist circumference gain during adulthood may be associated with higher CRC risk in men, thus highlighting the importance of maintaining a healthy waist for CRC prevention.

Indexed as

Body Fat DistributionWaist CircumferenceWaist-Hip RatioAdultAgedBody Mass IndexColorectal NeoplasmsFemaleFollow-Up StudiesHumansMaleMiddle AgedMultivariate AnalysisObesity, AbdominalProportional Hazards ModelsProspective StudiesBody fat distributionpostmenopausal hormone therapysex difference

Identifiers

PMID26403814
PMCPMC5005941
OpenAlexW2305753855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.