Evidence map›Paper›PMID 26403801›Full record

ReviewJournal of controlled release : official journal of the Controlled Release Society2015

Silk-based stabilization of biomacromolecules.

Adrian B Li, Jonathan A Kluge, Nicholas A Guziewicz, Fiorenzo G Omenetto, David L Kaplan

Abstract readReview
In one paragraph

Review in Journal of controlled release : official journal of the Controlled Release Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 145 citations in OpenAlex.

  1. Article
  2. Silk protein plastics for sustained and controlled drug release.International journal of pharmaceutics · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Silk Bioconjugates: From Chemistry and Concept to Application.ACS biomaterials science & engineering · 2024
    Review
  12. Article
  13. Inside-to-outside and back to the future of megakaryopoiesis.Research and practice in thrombosis and haemostasis · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Challenges in delivering therapeutic peptides and proteins: A silk-based solution.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Adrian B LiDepartment of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.
Jonathan A KlugeDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.
Nicholas A GuziewiczDrug Product Technologies, Amgen, 1 Amgen Center Drive, Thousand Oaks, CA 91320, USA.
Fiorenzo G OmenettoDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.
David L KaplanDepartment of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA; Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA. Electronic address: david.kaplan@tufts.edu.
Tufts University · USAmgen (United States) · US

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Craniofacial Tissue EngineeringR01DE016525 · NIDCR · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI VUNJAK-NOVAKOVIC, GORDANA · 2005 to 2017
$5.5M
Electrotherapeutic strategies for connective tissue repairR01AR061988 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI HUNG, CLARK T., KAPLAN, DAVID L. · 2011 to 2015
$3.3M
Tissue Regeneration by Biophysical SignalingR01AR055993 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L., LEVIN, MICHAEL · 2010 to 2018
$3.2M
Degradable orthopedic hardwareR01AR068048 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L., LIN, SAMUEL J · 2015 to 2020
$2.0M
NIAMS NIH HHS R01 AR055993NIAMS NIH HHS R01 AR061988NIAMS NIH HHS R01 AR068048NIBIB NIH HHS P41 EB002520NIDCR NIH HHS R01 DE016525
6 · The paper itself

Abstract

Silk fibroin is a high molecular weight amphiphilic protein that self-assembles into robust biomaterials with remarkable properties including stabilization of biologicals and tunable release kinetics correlated to processing conditions. Cells, antibiotics,monoclonal antibodies and peptides, among other biologics, have been encapsulated in silk using various processing approaches and material formats. The mechanistic basis for the entrapment and stabilization features, along with insights into the modulation of release of the entrained compounds from silks will be reviewed with a focus on stabilization of bioactive molecules.

Indexed as

Drug StabilityMacromolecular SubstancesSilkMacromolecular SubstancesSilkBiologicsInteractionsMechanismsProcessingRecoverySilkStabilization

Identifiers

PMID26403801
PMCPMC4656123
OpenAlexW1775999962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.