ReviewPediatric surgery international2015
Congenital diaphragmatic hernia, management in the newborn.
Review in Pediatric surgery international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A systematic review and meta-analysis of surgical morbidity of primary versus patch repaired congenital diaphragmatic hernia patients.Scientific reports · 2021Pooled it
- Initiating resuscitation before umbilical cord clamping in infants with congenital diaphragmatic hernia: a pilot feasibility trial.Archives of disease in childhood. Fetal and neonatal edition · 2020Trial
- Development of an age-adapted simplified acute physiology score II using first-24-hour variables in pediatric patients with congenital diaphragmatic hernia: the CDH-SAPS.European journal of pediatrics · 2026Article
- Delayed presentation of congenital diaphragmatic hernia: A report of 2 cases.Radiology case reports · 2024Article
- Risk factors for mortality in infants with congenital diaphragmatic hernia: a single center experience.Wiener klinische Wochenschrift · 2021Observational
- Perinatal stabilisation of infants born with congenital diaphragmatic hernia: a review of current concepts.Archives of disease in childhood. Fetal and neonatal edition · 2020Review
- Congenital diaphragmatic hernia presenting with symptoms within the first day of life; outcomes from a non-ECMO centre in Denmark.BMC pediatrics · 2020Article
- A comparative study of thoracoscopic and open surgery of congenital diaphragmatic hernia in neonates.Journal of cardiothoracic surgery · 2019Article
- Article
- Evaluating the utility of the "late ECMO repair": a congenital diaphragmatic hernia study group investigation.Pediatric surgery international · 2018Article
- Expression of T-box transcription factors 2, 4 and 5 is decreased in the branching airway mesenchyme of nitrofen-induced hypoplastic lungs.Pediatric surgery international · 2017Article
- Downregulation of Forkhead box F1 gene expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.Pediatric surgery international · 2016Article
- Thoracoscopic Approach for Congenital Diaphragmatic Hernia: A Useful Tool in Diagnosis and Treatment of Unexpected Associated Lung Lesion.European journal of pediatric surgery reports · 2016Article
- Decreased expression of hepatocyte growth factor in the nitrofen model of congenital diaphragmatic hernia.Pediatric surgery international · 2016Article
- Congenital diaphragmatic hernia in neonates: Open versus thoracoscopic repair.African journal of paediatric surgery : AJPSArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital diaphragmatic hernia (CDH) in the newborn poses challenges to the multi-disciplinary teams involved in its management. Mortality remains significantly high, despite growing understanding and treatment options. Early intubation of antenatally diagnosed cases is crucial in preventing deterioration and persistent pulmonary hypertension. Early recognition of cases not diagnosed on antenatal scan, with appreciation of differential diagnosis, requires an index of suspicion and imaging. Increasing options and modalities are available, with only modest, if any, survival advantage. Permissive hypercapnea and minimal ventilation have made the most significant impact on survival in modern era. High-frequency oscillatory ventilation (HFOV), inhaled nitric oxide (iNO), treatment of pulmonary hypertension, and ECMO are used in a somewhat stepwise manner for stabilisation. Delayed surgery has become established later in management plan. The impact of individual therapies (e.g. HFOV, iNO, ECMO) on outcome is difficult to ascertain. Little level 1 or 2 evidence exists. Randomised studies and reviews on the role of ECMO have not yet proven any long-term survival benefit. One pilot randomised study of thoracoscopic repair suggests increased acidosis; intraoperative blood gases and CO2 levels should be closely monitored. Monitoring tissue oxygenation should be considered. There is no evidence to suggest the best patch material.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.