ReviewCellular and molecular life sciences : CMLS2016
Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity.
Review in Cellular and molecular life sciences : CMLS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 58 citations in OpenAlex.
- Temporal Interactome Mapping of Human Tau in Drosophila Reveals Progressive Mitochondrial Engagement and Porin/VDAC1-Dependent Modulation of Toxicity.International journal of molecular sciences · 2025Article
- The formation of small aggregates contributes to the neurotoxic effects of tauNeurochemistry international · 2022Article
- Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer's disease and other tauopathies.Brain pathology (Zurich, Switzerland) · 2021Article
- Modeling tau transport in the axon initial segment.Mathematical biosciences · 2020Article
- The Role of Copper in Tau-Related Pathology in Alzheimer's Disease.Frontiers in molecular neuroscience · 2020Review
- Tau immunotherapies for Alzheimer's disease.Expert opinion on investigational drugs · 2019Review
- Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved.Frontiers in molecular neuroscience · 2019Review
- TauNeuroscience · 2017Article
- Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease.Neurobiology of aging · 2017Article
- Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag.Protein expression and purification · 2017Article
- Pyrrolo[2,3-c]pyridines as Imaging Agents for Neurofibrilary Tangles.ACS medicinal chemistry letters · 2016Article
- Tau Structures.Frontiers in aging neuroscience · 2016Review
- Abnormal Hyperphosphorylation of Tau in Canine Immune-mediated Meningoencephalitis.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
tau, a microtubule-associated protein, directly binds with microtubules to dynamically regulate the organization of cellular cytoskeletons, and is especially abundant in neurons of the central nervous system. Under disease conditions such as Pick's disease, progressive supranuclear palsy, frontotemporal dementia, parkinsonism linked to chromosome 17 and Alzheimer's disease, tau proteins can self-assemble to paired helical filaments progressing to neurofibrillary tangles. In these diseases, collectively referred to as "tauopathies", alterations of diverse tau modifications including phosphorylation, metal ion binding, glycosylation, as well as structural changes of tau proteins have all been observed, indicating the complexity and variability of factors in the regulation of tau toxicity. Here, we review our current knowledge and hypotheses from relevant studies on tau toxicity, emphasizing the roles of phosphorylations, metal ions, folding and clearance control underlining tau etiology and their regulations. A summary of clinical efforts and associated findings of drug candidates under development is also presented. It is hoped that a more comprehensive understanding of tau regulation will provide us with a better blueprint of tau networking in neuronal cells and offer hints for the design of more efficient strategies to tackle tau-related diseases in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.