ArticleUltrasound in medicine & biology2015
Characterization of Bioeffects on Endothelial Cells under Acoustic Droplet Vaporization.
Article in Ultrasound in medicine & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
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Who cites it
21 citing papers in PubMed.
- Real-time spatiotemporal characterization of mechanics and sonoporation of acoustic droplet vaporization in acoustically responsive scaffolds.Applied physics letters · 2023Article
- The Evolution and Recent Trends in Acoustic Targeting of Encapsulated Drugs to Solid Tumors: Strategies beyond Sonoporation.Pharmaceutics · 2023Review
- Perfluorocarbon nanodroplet size, acoustic vaporization, and inertial cavitation affected by lipid shell composition in vitro.The Journal of the Acoustical Society of America · 2022Article
- Recent Progress Toward Imaging Application of Multifunction Sonosensitizers in Sonodynamic Therapy.International journal of nanomedicine · 2022Review
- Ultrasonic technologies in imaging and drug delivery.Cellular and molecular life sciences : CMLS · 2021Review
- Improving Release of Liposome-Encapsulated Drugs with Focused Ultrasound and Vaporizable Droplet-Liposome Nanoclusters.Pharmaceutics · 2021Article
- A Highly Efficient One-for-All Nanodroplet for Ultrasound Imaging-Guided and Cavitation-Enhanced Photothermal Therapy.International journal of nanomedicine · 2021Article
- Spatially localized sono-photoacoutic activation of phase-change contrast agents.Photoacoustics · 2020Article
- Combined gas embolization and chemotherapy can result in complete tumor regression in a murine hepatocellular carcinoma model.APL bioengineering · 2020Article
- Opto-acoustic synergistic irradiation for vaporization of natural melanin-cored nanodroplets at safe energy levels and efficient sono-chemo-photothermal cancer therapy.Theranostics · 2020Article
- Minimally invasive gas embolization using acoustic droplet vaporization in a rodent model of hepatocellular carcinoma.Scientific reports · 2019Article
- Spontaneous Nucleation of Stable Perfluorocarbon Emulsions for Ultrasound Contrast Agents.Nano letters · 2019Article
- Review on Acoustic Droplet Vaporization in Ultrasound Diagnostics and Therapeutics.BioMed research international · 2019Review
- Gas Embolization in a Rodent Model of Hepatocellular Carcinoma Using Acoustic Droplet Vaporization.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2018Article
- Spatial-Temporal Cellular Bioeffects from Acoustic Droplet Vaporization.Theranostics · 2018Article
- Controlled release of basic fibroblast growth factor for angiogenesis using acoustically-responsive scaffolds.Biomaterials · 2017Article
- PEGylated PLGA-based phase shift nanodroplets combined with focused ultrasound for blood brain barrier opening in rats.Oncotarget · 2017Article
- Laser-Activated Polymeric Microcapsules for Ultrasound Imaging and Therapy: In Vitro Feasibility.Biophysical journal · 2017Article
- An evaluation of the sonoporation potential of low-boiling point phase-change ultrasound contrast agents in vitro.Journal of therapeutic ultrasound · 2017Article
- Theranostic Performance of Acoustic Nanodroplet Vaporization-Generated Bubbles in Tumor Intertissue.Theranostics · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Gas embolotherapy is achieved by locally vaporizing microdroplets through acoustic droplet vaporization, which results in bubbles that are large enough to occlude blood flow directed to tumors. Endothelial cells, lining blood vessels, can be affected by these vaporization events, resulting in cell injury and cell death. An idealized monolayer of endothelial cells was subjected to acoustic droplet vaporization using a 3.5-MHz transducer and dodecafluoropentane droplets. Treatments included insonation pressures that varied from 2 to 8 MPa (rarefactional) and pulse lengths that varied from 4 to 16 input cycles. The bubble cloud generated was directly dependent on pressure, but not on pulse length. Cellular damage increased with increasing bubble cloud size, but was limited to the bubble cloud area. These results suggest that vaporization near the endothelium may impact the vessel wall, an effect that could be either deleterious or beneficial depending on the intended overall therapeutic application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.