ReviewBritish journal of pharmacology2015
Integration of reward signalling and appetite regulating peptide systems in the control of food-cue responses.
Review in British journal of pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Effects of Essential Oils and Fragrant Compounds on Appetite: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Food Noise Among Healthcare Students and Healthcare Professionals in Al-Ahsa, Saudi Arabia: A Cross-Sectional Study.Nutrients · 2026Article
- Ethinyl estradiol and levonorgestrel coadministration induces hypophagia and increases energy expenditure in female rats.Endocrinology · 2026Article
- Exploring the association between hedonic hunger and obesogenic eating behaviors in females with overweight/obesity using machine learning methods.Scientific reports · 2026Article
- Examining the Effect of Virtual Reality-Based Fast-Food Marketing on Eating-Related Outcomes in Young Adults: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Appetite Self-Regulation in Childhood: A Narrative Review and Conceptual Model of Processes and Mechanisms With Implications for Research and Practice.Nutrition reviews · 2025Review
- An alternative neural basis underlying leptin resistance.Cell reports · 2025Article
- Aberrant brain network connectivity related to cognitive and emotional regulation in women with abdominal obesity.Scientific reports · 2025Article
- Soy-Based High-Protein Spheric Foods with the Appearance of Familiar Sugary Snacks.Foods (Basel, Switzerland) · 2024Article
- Orexins in apoptosis: a dual regulatory role.Frontiers in cellular neuroscience · 2024Review
- Vagal Stimulation Ameliorates Non-Alcoholic Fatty Liver Disease in Rats.Biomedicines · 2023Article
- Sucralose Targets the Insulin Signaling Pathway in the SH-SY5Y Neuroblastoma Cell Line.Metabolites · 2023Article
- Food memory circuits regulate eating and energy balance.Current biology : CB · 2023Article
- The Role of Molecular and Hormonal Factors in Obesity and the Effects of Physical Activity in Children.International journal of molecular sciences · 2022Review
- Food cue reactivity: Neurobiological and behavioral underpinnings.Reviews in endocrine & metabolic disorders · 2022Review
- Satiety Associated with Calorie Restriction and Time-Restricted Feeding: Central Neuroendocrine Integration.Advances in nutrition (Bethesda, Md.) · 2022Review
- Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis.Molecular psychiatry · 2022Article
- BDNF influences neural cue-reactivity to food stimuli and food craving in obesity.European archives of psychiatry and clinical neuroscience · 2021Article
- Decoding the Role of Gut-Microbiome in the Food Addiction Paradigm.International journal of environmental research and public health · 2021Review
- Effects of exercise and diet intervention on appetite-regulating hormones associated with miRNAs in obese children.Eating and weight disorders : EWD · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the neurobiological substrates that encode learning about food-associated cues and how those signals are modulated is of great clinical importance especially in light of the worldwide obesity problem. Inappropriate or maladaptive responses to food-associated cues can promote over-consumption, leading to excessive energy intake and weight gain. Chronic exposure to foods rich in fat and sugar alters the reinforcing value of foods and weakens inhibitory neural control, triggering learned, but maladaptive, associations between environmental cues and food rewards. Thus, responses to food-associated cues can promote cravings and food-seeking by activating mesocorticolimbic dopamine neurocircuitry, and exert physiological effects including salivation. These responses may be analogous to the cravings experienced by abstaining drug addicts that can trigger relapse into drug self-administration. Preventing cue-triggered eating may therefore reduce the over-consumption seen in obesity and binge-eating disorder. In this review we discuss recent research examining how cues associated with palatable foods can promote reward-based feeding behaviours and the potential involvement of appetite-regulating peptides including leptin, ghrelin, orexin and melanin concentrating hormone. These peptide signals interface with mesolimbic dopaminergic regions including the ventral tegmental area to modulate reactivity to cues associated with palatable foods. Thus, a novel target for anti-obesity therapeutics is to reduce non-homeostatic, reward driven eating behaviour, which can be triggered by environmental cues associated with highly palatable, fat and sugar rich foods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.