Evidence map›Paper›PMID 26403512›Full record

ArticleLa Radiologia medica2016

Prognostic factors in patients with locally advanced head and neck cancer treated with concurrent radiochemotherapy.

Davide Franceschini, Fabiola Paiar, Calogero Saieva, Pierluigi Bonomo, Benedetta Agresti, Icro Meattini, Daniela Greto, Monica Mangoni, Fiammetta Meacci, Mauro Loi and 3 more

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Article in La Radiologia medica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2017
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Davide FranceschiniDepartment of Radiation-Oncology, University of Florence, Florence, Italy. davide.franceschini@unifi.it.
Fabiola PaiarDepartment of Radiation-Oncology, University of Florence, Florence, Italy.
Calogero SaievaMolecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Center (ISPO), Florence, Italy.
Pierluigi BonomoDepartment of Radiation-Oncology, University of Florence, Florence, Italy.
Benedetta AgrestiDepartment of Radiation-Oncology, University of Florence, Florence, Italy.
Icro MeattiniDepartment of Radiation-Oncology, University of Florence, Florence, Italy.
Daniela GretoDepartment of Radiation-Oncology, University of Florence, Florence, Italy.
Monica MangoniDepartment of Radiation-Oncology, University of Florence, Florence, Italy.
Fiammetta MeacciDepartment of Radiation-Oncology, University of Florence, Florence, Italy.
Mauro LoiDepartment of Radiation-Oncology, University of Florence, Florence, Italy.
Giacomo ZeiDepartment of Radiation-Oncology, University of Florence, Florence, Italy.
Lorenzo LiviDepartment of Radiation-Oncology, University of Florence, Florence, Italy.
Giampaolo BitiDepartment of Radiation-Oncology, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study was undertaken to evaluate the association of individual parameters and outcome in patients with unresectable locally advanced head and neck cancer treated with radiochemotherapy. MATERIALS AND

methodsWe retrospectively reviewed data from 126 patients treated in our Institution between 1998 and 2010 for a locally advanced head and neck cancer. Sixteen individual parameters were evaluated for association with specific outcomes such as overall survival, persistence of disease, disease-specific survival and disease-free survival.

resultsSix factors influenced overall survival on Kaplan-Meier survival analysis and on univariate Cox regression analysis: smoking, body mass index, site, haemoglobin (Hb) nadir, total dose of radiotherapy and comorbidities. On a multivariate logistic model with stepwise selection, comorbidities, body mass index, total dose and site maintained significance. A significant association for persistence of disease was found with smoking, Hb nadir and site of cancer on univariate and multivariate analysis. Disease-free survival was correlated with performance status, Hb nadir and comorbidities using Kaplan-Meier survival analysis and on univariate Cox regression analysis. Only performance status maintained the significance on multivariate analysis. Disease-specific survival was correlated with five parameters: body mass index, site, Hb nadir, therapy interruption and total dose; on multivariate analysis, Hb nadir, therapy interruption and site maintained a statistically significant association.

conclusionsHb nadir during treatment, body mass index, smoking, stage, comorbidities and performance status are prognostic factors of outcome and response to radical treatment with radiochemotherapy.

Indexed as

ChemoradiotherapyAdultAgedFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRetrospective StudiesRisk FactorsTreatment OutcomeHead and neckOncologyPrognostic factorsRadiation therapy

Identifiers

PMID26403512

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.