Evidence map›Paper›PMID 26403511›Full record

ReviewStem cell reviews and reports2016

Engineering Cell Fate for Tissue Regeneration by In Vivo Transdifferentiation.

I de Lázaro, K Kostarelos

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

I de LázaroNanomedicine Lab, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, The University of Manchester, AV Hill Building, Manchester, M13 9PT, UK. irene.delazarodelrey@manchester.ac.uk.
K KostarelosNanomedicine Lab, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, The University of Manchester, AV Hill Building, Manchester, M13 9PT, UK. kostas.kostarelos@manchester.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in cell identity occur in adult mammalian organisms but are rare and often linked to disease. Research in the last few decades has thrown light on how to manipulate cell fate, but the conversion of a particular cell type into another within a living organism (also termed in vivo transdifferentiation) has only been recently achieved in a limited number of tissues. Although the therapeutic promise of this strategy for tissue regeneration and repair is exciting, important efficacy and safety concerns will need to be addressed before it becomes a reality in the clinical practice. Here, we review the most relevant in vivo transdifferentiation studies in adult mammalian animal models, offering a critical assessment of this potentially powerful strategy for regenerative medicine.

Indexed as

Cellular ReprogrammingAdenoviridaeAnimalsCell EngineeringCell TransdifferentiationDisease Models, AnimalGenetic VectorsHepatocytesHumansInduced Pluripotent Stem CellsInsulin-Secreting CellsMyocytes, CardiacNeuronsRegenerationRegenerative MedicineCell fateRegenerationReprogrammingTissue repairTransdifferentiation

Identifiers

PMID26403511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.