Evidence map›Paper›PMID 26403472›Full record

Trial reportBMC oral health2015

Effect of probiotic chewing tablets on early childhood caries--a randomized controlled trial.

Trifa Hedayati-Hajikand, Ulrika Lundberg, Catarina Eldh, Svante Twetman

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01720771 (Preventive Effect of a Probiotic Tablet on Oral Health in Preschool Children), which is not on this map. Cited by 39 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 7 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01720771 nacompletednot on this map

Preventive Effect of a Probiotic Tablet on Oral Health in Preschool Children

TypeinterventionalSponsorUniversity of CopenhagenRan2013 to 2015Enrolled138ConditionsDental CariesArmsprobiotic tablet, sugar pill
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 7 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Effect of a Short-Term Intervention withInternational journal of environmental research and public health · 2022
    Trial
  9. Trial
  10. Trial
  11. Trial
  12. Review
  13. Oral hygiene agents at work: effects onFrontiers in cellular and infection microbiology · 2026
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Trifa Hedayati-HajikandPublic Dental Care Service, Scania Region, Sweden. trifa.hedayati-hajikand@regionorebrolan.se.
Ulrika LundbergPublic Dental Care Service, Scania Region, Sweden. ulrika.lundberg@skane.se.
Catarina EldhPublic Dental Care Service, Scania Region, Sweden. catarina.eldh@skane.se.
Svante TwetmanDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Allé 20, 2200, Copenhagen, Denmark. stwe@sund.ku.dk.
Public Dental Service Västra Götaland · SEScania (Sweden) · SEUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the effect of probiotic chewing tablets on early childhood caries development in preschool children living in a low socioeconomic multicultural area.

methodsThe investigation employed a randomized double-blind placebo-controlled design. The study group consisted of 138 healthy 2-3-year-old children that were consecutively recruited after informed parental consent. After enrollment, they were randomized to a test or a placebo group. The parents of the test group were instructed to give their child one chewing tablet per day containing three strains of live probiotic bacteria (ProBiora3) and the placebo group got identical tablets without bacteria. The duration was one year and the prevalence and increment of initial and manifest caries lesions was examined at baseline and follow-up. All parents were thoroughly instructed to brush the teeth of their off-springs twice daily with fluoride toothpaste.

resultsThe groups were balanced at baseline and the attrition rate was 20%. Around 2/3 of the children in both groups reported an acceptable compliance. The caries increment (Δds) was significantly lower in the test group when compared with the placebo group, 0.2 vs. 0.8 (p < 0.05). The risk reduction was 0.47 (95% CI 0.24-0.98) and the number needed to treat close to five. No differences were displayed between the groups concerning presence of visible plaque or bleeding-on-brushing. No side effects were reported.

conclusionsThe results suggested that early childhood caries development could be reduced through administration of these probiotic chewing tablets as adjunct to daily use of fluoride toothpaste in preschool children. Further studies on a possible dose-response relationship seem justified

trial registrationClinicalTrials.gov Identifier: NCT01720771 . First received: October 31, 2012.

Indexed as

Cariostatic AgentsChild, PreschoolCultural DiversityDental CariesDental PlaqueDMF IndexDouble-Blind MethodFemaleFluoridesFollow-Up StudiesHumansIntention to Treat AnalysisMalePeriodontal IndexPlacebosPovertyCariostatic AgentsFluoridesPlacebosTabletsToothpastes

Identifiers

PMID26403472
PMCPMC4583156
OpenAlexW2121443207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.