ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2015
Favorable patient reported outcomes following IMRT for early carcinomas of the tonsillar fossa: Results from a symptom assessment study.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- A randomized, double-blind, placebo controlled, phase II study to evaluate the efficacy of ginseng in reducing fatigue in patients treated for head and neck cancer.Journal of cancer research and clinical oncology · 2020Trial
- Patient-reported outcomes after ipsilateral radiation therapy for N2b tonsillar squamous cell carcinoma.Discover oncology · 2025Article
- Patient-Reported Outcomes-Guided Adaptive Radiation Therapy for Head and Neck Cancer.Frontiers in oncology · 2021Article
- Prospective observational evaluation of radiation-induced late taste impairment kinetics in oropharyngeal cancer patients: Potential for improvement over time?Clinical and translational radiation oncology · 2020Article
- Patient-reported quality of life and toxicity in unilateral and bilateral radiotherapy for early-stage human papillomavirus associated tonsillar carcinoma.Clinical and translational radiation oncology · 2020Article
- Symptom Burden in Long-Term Survivors of Head and Neck Cancer: Patient-Reported Versus Clinical Data.EGEMS (Washington, DC) · 2019Article
- Fatigue following radiation therapy in nasopharyngeal cancer survivors: A dosimetric analysis incorporating patient report and observer rating.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2019Article
- Patient reported dry mouth: Instrument comparison and model performance for correlation with quality of life in head and neck cancer survivors.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2018Article
- Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients ≥65 years old.Radiation oncology (London, England) · 2017Article
- Radiation therapy (with or without neck surgery) for phenotypic human papillomavirus-associated oropharyngeal cancer.Cancer · 2016Article
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundA questionnaire-based study was conducted to assess long-term patient reported outcomes (PROs) following definitive IMRT-based treatment for early stage carcinomas of the tonsillar fossa.
methodsParticipants had received IMRT with or without systemic therapy for squamous carcinoma of the tonsillar fossa (T1-2 and N0-2b) with a minimum follow-up of 2years. Patients completed a validated head and neck cancer-specific PRO instrument, the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN). Symptoms were compared between treatment groups of interest and overall symptom burden was evaluated.
resultsOf 139 participants analyzed, 51% had received ipsilateral neck IMRT, and 62% single modality IMRT alone (no systemic therapy). There were no differences in mean severity ratings for the top-ranked individual symptoms or symptom interference for those treated with bilateral versus ipsilateral neck IMRT alone. However, 40% of those treated with bilateral versus 25% of those treated with ipsilateral neck RT alone reported moderate-to-severe levels of dry mouth (p=0.03). Fatigue, numbness/tingling, and constipation were rated more severe for those who had received systemic therapy (p<0.05 for each), but absolute differences were small. Overall, 51% had no more than mild symptom ratings across all 22 symptoms assessed.
conclusionsThe long-term patient reported symptom profile in this cohort of tonsil cancer survivors treated with definitive IMRT-based treatment showed a majority of patients with no more than mild symptoms, low symptom interference, and provides an opportunity for future comparison studies with other treatment approaches.
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