Observational studyPLoS neglected tropical diseases2015
Economic Impact of Dengue: Multicenter Study across Four Brazilian Regions.
Observational study in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Economic Impact of Dengue Virus in Mexico Over One Decade: A Systematic Literature Review (2010-2020).The International journal of health planning and management · 2026Pooled it
- The economic burden of dengue: a systematic literature review of unit costs for non-fatal episodes treated in the formal healthcare system.BMC infectious diseases · 2026Pooled it
- Systematic review of dengue vaccine efficacy.BMC infectious diseases · 2019Pooled it
- A systematic review of the economic impact of rapid diagnostic tests for dengue.BMC health services research · 2017Pooled it
- Is Dengue Vector Control Deficient in Effectiveness or Evidence?: Systematic Review and Meta-analysis.PLoS neglected tropical diseases · 2016Pooled it
- Resource Use and Costs of Dengue: Analysis of Data from Phase III Efficacy Studies of a Tetravalent Dengue Vaccine.The American journal of tropical medicine and hygiene · 2017Trial
- A prospective cohort study to assess seroprevalence, incidence, knowledge, attitudes and practices, willingness to pay for vaccine and related risk factors in dengue in a high incidence setting.BMC infectious diseases · 2016Trial
- Epidemiological and digital syndromic surveillance data on dengue, chikungunya, and SARI in Brazil.Scientific data · 2026Article
- Beyond DALY: public funding of health innovation in Brazil as a political strategy for equity in the Global South.BMC public health · 2025Article
- Long-Term Durability and Public Health Impact of City-WideTropical medicine and infectious disease · 2025Article
- Understanding Dengue Underreporting: An Analysis of the Impacts for the World, Latin America and Brazil.TheScientificWorldJournal · 2025Review
- The macroeconomic impact of a dengue outbreak: Case studies from Thailand and Brazil.PLoS neglected tropical diseases · 2024Article
- Article
- Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil.Tropical medicine and infectious disease · 2023Review
- Transgene-induced cell death following dengue-2 virus infection in Aedes aegypti.Scientific reports · 2023Article
- Knowledge, attitudes, and practices of Crimean Congo hemorrhagic fever among livestock value chain actors in Kagadi district, Uganda.PLoS neglected tropical diseases · 2023Article
- Article
- Genome evolution of dengue virus serotype 1 under selection byVirus evolution · 2023Article
- Potential Nosocomial Infections by the Zika and Chikungunya Viruses in Public Health Facilities in the Metropolitan Area of Recife, Brazil.Tropical medicine and infectious disease · 2022Article
- How heterogeneous is the dengue transmission profile in Brazil? A study in six Brazilian states.PLoS neglected tropical diseases · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue is an increasing public health concern in Brazil. There is a need for an updated evaluation of the economic impact of dengue within the country. We undertook this multicenter study to evaluate the economic burden of dengue in Brazil.
methodsWe estimated the economic burden of dengue in Brazil for the years 2009 to 2013 and for the epidemic season of August 2012- September 2013. We conducted a multicenter cohort study across four endemic regions: Midwest, Goiania; Southeast, Belo Horizonte and Rio de Janeiro; Northeast: Teresina and Recife; and the North, Belem. Ambulatory or hospitalized cases with suspected or laboratory-confirmed dengue treated in both the private and public sectors were recruited. Interviews were scheduled for the convalescent period to ascertain characteristics of the dengue episode, date of first symptoms/signs and recovery, use of medical services, work/school absence, household spending (out-of-pocket expense) and income lost using a questionnaire developed for a previous cost study. We also extracted data from the patients' medical records for hospitalized cases. Overall costs per case and cumulative costs were calculated from the public payer and societal perspectives. National cost estimations took into account cases reported in the official notification system (SINAN) with adjustment for underreporting of cases. We applied a probabilistic sensitivity analysis using Monte Carlo simulations with 90% certainty levels (CL).
resultsWe screened 2,223 cases, of which 2,035 (91.5%) symptomatic dengue cases were included in our study. The estimated cost for dengue for the epidemic season (2012-2013) in the societal perspective was US$ 468 million (90% CL: 349-590) or US$ 1,212 million (90% CL: 904-1,526) after adjusting for under-reporting. Considering the time series of dengue (2009-2013) the estimated cost of dengue varied from US$ 371 million (2009) to US$ 1,228 million (2013).
conclusionsThe economic burden associated with dengue in Brazil is substantial with large variations in reported cases and consequently costs reflecting the dynamic of dengue transmission.
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