ReviewNutrients2015
Early Life Nutrition and Energy Balance Disorders in Offspring in Later Life.
Review in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- ILSI Europe Systematic Review: The Impact of Digestible and Nondigestible Carbohydrate Consumption for Toddlers (1-4 Years) in Relation to Health Outcomes.Nutrition reviews · 2025Pooled it
- Perceived stress and diet quality in women of reproductive age: a systematic review and meta-analysis.Nutrition journal · 2020Pooled it
- An exploratory study of clinical factors associated with IGF-1 and IGFBP-3 in preterm infants.Pediatric research · 2024Trial
- Growth, metabolic markers, and cognition in 8-year old children born prematurely, follow-up of a randomized controlled trial with essential fatty acids.European journal of pediatrics · 2016Trial
- The Potential Physiologic Mechanisms by Which Early-Life Nutrition May Influence Type 2 Diabetes Pathophysiology in Humans.Annual review of nutrition · 2026Review
- Review
- Maternal probiotic and prebiotic supplementation on glucose metabolism in pregnant women and their offspring: effects and related mechanisms.Frontiers in microbiology · 2026Review
- Association between Eating-Fasting and Sleep-Wake Cycles with Eating Times and Food Consumption throughout the Day: Longitudinal Study with Pregnant Women.Sleep science (Sao Paulo, Brazil) · 2025Article
- Interindividual differences of dietary fat-inducible Mest in white adipose tissue of C57BL/6J mice are not heritable.Obesity (Silver Spring, Md.) · 2024Article
- Atherosclerosis originating from childhood: Specific features.Journal of biomedical research · 2024Article
- Defining postnatal growth failure among preterm infants in Indonesia.Frontiers in nutrition · 2023Article
- Early Life Low-Calorie Sweetener Consumption Impacts Energy Balance during Adulthood.Nutrients · 2022Article
- Cord blood adiponectin and leptin are associated with a lower risk of stunting during infancy.Scientific reports · 2022Article
- Maternal High-Fructose Intake Activates Myogenic Program in Fetal Brown Fat and Predisposes Offspring to Diet-Induced Metabolic Dysfunctions in Adulthood.Frontiers in nutrition · 2022Article
- Trimester two gestational exposure to bisphenol A and adherence to mediterranean diet are associated with adolescent offspring oxidative stress and metabolic syndrome risk in a sex-specific manner.Frontiers in nutrition · 2022Article
- Are Brain and Cognitive Reserve Shaped by Early Life Circumstances?Frontiers in neuroscience · 2022Review
- Time-Restricted Feeding during Puberty Ameliorates Adiposity and Prevents Hepatic Steatosis in a Mouse Model of Childhood Obesity.Nutrients · 2021Article
- Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development.Biomolecules · 2021Review
- Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health.Cell metabolism · 2021Article
- The Triad Mother-Breast Milk-Infant as Predictor of Future Health: A Narrative Review.Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global pandemic of obesity and type 2 diabetes is often causally linked to changes in diet and lifestyle; namely increased intake of calorically dense foods and concomitant reductions in physical activity. Epidemiological studies in humans and controlled animal intervention studies have now shown that nutritional programming in early periods of life is a phenomenon that affects metabolic and physiological functions throughout life. This link is conceptualised as the developmental programming hypothesis whereby environmental influences during critical periods of developmental plasticity can elicit lifelong effects on the health and well-being of the offspring. The mechanisms by which early environmental insults can have long-term effects on offspring remain poorly defined. However there is evidence from intervention studies which indicate altered wiring of the hypothalamic circuits that regulate energy balance and epigenetic effects including altered DNA methylation of key adipokines including leptin. Studies that elucidate the mechanisms behind these associations will have a positive impact on the health of future populations and adopting a life course perspective will allow identification of phenotype and markers of risk earlier, with the possibility of nutritional and other lifestyle interventions that have obvious implications for prevention of non-communicable diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.