ReviewInternational journal of molecular sciences2015
The Current Role of Omega-3 Fatty Acids in the Management of Atrial Fibrillation.
Review in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Serum albumin levels and risk of atrial fibrillation: a Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
- Resolution-promoting autacoids demonstrate promising cardioprotective effects against heart diseases.Molecular biology reports · 2022Review
- Novel Combined Antioxidant Strategy against Hypertension, Acute Myocardial Infarction and Postoperative Atrial Fibrillation.Biomedicines · 2021Review
- The Effects of Fish Oil on Cardiovascular Diseases: Systematical Evaluation and Recent Advance.Frontiers in cardiovascular medicine · 2021Review
- Atrial fibrillation type modulates the clinical predictive value of neutrophil-to-lymphocyte ratio for atrial fibrillation recurrence after catheter ablation.International journal of cardiology. Heart & vasculature · 2020Article
- Cardiovascular, electrophysiologic, and hematologic effects of omega-3 fatty acids beyond reducing hypertriglyceridemia: as it pertains to the recently published REDUCE-IT trial.Cardiovascular diabetology · 2019Review
- Inflammation and atrial fibrillation: A comprehensive review.Journal of arrhythmia · 2018Review
- Current Evidence about Nutrition Support in Cardiac Surgery Patients-What Do We Know?Nutrients · 2018Review
- Atrial fibrillation in immigrant groups: a cohort study of all adults 45 years of age and older in Sweden.European journal of epidemiology · 2017Article
- Sea food consumption for improving cardiac and cerebral manifestations of mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes.Annals of translational medicine · 2017Article
- Omega-3 Fatty Acids Supplementation Differentially Modulates the SDF-1/CXCR-4 Cell Homing Axis in Hypertensive and Normotensive Rats.Nutrients · 2017Article
- Enriching Diet with n-3 PUFAs to Help Prevent Cardiovascular Diseases in Healthy Adults: Results from Clinical Trials.International journal of molecular sciences · 2017Review
- Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization.Pharmacology & therapeutics · 2016Review
- Progressing Insights into the Role of Dietary Fats in the Prevention of Cardiovascular Disease.Current cardiology reports · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe main dietary source of omega-3 polyunsaturated fatty acids (n-3 PUFA) is fish, which contains eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In the present manuscript, we aimed to review the current evidence regarding the clinical role of n-3 PUFA in the prevention of atrial fibrillation (AF) and the possible underlying mechanisms.
methodsA literature search based on PubMed listings was performed using "Omega-3 fatty acids" and "atrial fibrilation" as key search terms.
resultsn-3 PUFA have been shown to attenuate structural atrial remodeling, prolong atrial effective refractory period through the prevention of reentry and suppress ectopic firing from pulmonary veins. Dietary fish intake has been found to have no effect on the incidence of AF in the majority of studies. Circulating DHA has been consistently reported to be inversely associated with AF risk, whereas EPA has no such effect. The majority of studies investigating the impact of n-3 PUFA supplementation on the incidence of AF following cardiac surgery reported no benefit, though most of them did not use n-3 PUFA pretreatment for adequate duration. Studies using adequate four-week pretreatment with n-3 PUFA before cardioversion of AF showed a reduction of the AF incidence.
conclusionsAlthough n-3 PUFA have antiarrhythmogenic properties, their clinical efficacy on the prevention of AF is not consistently supported. Further well-designed studies are needed to overcome the limitations of the existing studies and provide robust conclusions.
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