ArticleNeuron2015
The Necessity of Rostrolateral Prefrontal Cortex for Higher-Level Sequential Behavior.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 113 citations in OpenAlex.
- What is common to memory retrieval and relational reasoning? Testing neural overlap in anterior lateral prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Visual Simulation Is Supported by Sequential Monitoring in the Lateral Prefrontal Cortex.Journal of cognitive neuroscience · 2026Article
- Obsessive-compulsive disorder and abstract sequence task contributions shift prefrontal cortical connectivity.bioRxiv : the preprint server for biology · 2026Article
- Integrated Representations of Threat and Controllability in the Lateral Frontal Pole.Journal of cognitive neuroscience · 2026Article
- Habit learning is associated with efficiently controlled network dynamics in naive macaque monkeys.Npj complexity · 2026Article
- Complex functions of human lateral frontopolar cortex.Brain : a journal of neurology · 2025Review
- Motor and Cognitive Sequence Tasks Exhibit Different Ramping Patterns in Parietal and Prefrontal Cortices.Journal of cognitive neuroscience · 2025Article
- Addressing Altered Anticipation as a Transdiagnostic Target Through Computational Psychiatry.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Ramping dissociates motor and cognitive sequences in the parietal and prefrontal cortices.bioRxiv : the preprint server for biology · 2025Article
- Multiple insular-prefrontal pathways underlie perception to execution during response inhibition in humans.Nature communications · 2024Article
- Abstract task sequence initiation deficit dissociates anxiety disorders from obsessive-compulsive disorder and healthy controls.Cognitive, affective & behavioral neuroscience · 2024Article
- Different Subregions of Monkey Lateral Prefrontal Cortex Respond to Abstract Sequences and Their Components.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Different subregions of monkey lateral prefrontal cortex respond to abstract sequences and their components.bioRxiv : the preprint server for biology · 2024Article
- The timing of confidence computations in human prefrontal cortex.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Feature Integration in Motor Sequences: Implications for Abstract Task Sequence Studies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Chunking of Control: An Unrecognized Aspect of Cognitive Resource Limits.Journal of cognition · 2023Article
- What Does the Frontopolar Cortex Contribute to Goal-Directed Cognition and Action?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis.Neuroscience and biobehavioral reviews · 2022Review
- Prefrontal contributions to the stability and variability of thought and conscious experience.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Front and center: Maturational dysregulation of frontal lobe functional neuroanatomic connections in attention deficit hyperactivity disorder.Frontiers in neuroanatomy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Frontal neocortex is thought to support our highest intellectual abilities, including our ability to plan and enact a sequence of tasks toward a desired goal. In everyday life, such task sequences are abstract in that they do not require consistent movement sequences and are often assembled "on the fly." Yet, remarkably little is known about the necessity of frontal sub-regions for such control. Participants repeatedly completed sequences of simple tasks during fMRI scanning. Rostrolateral prefrontal cortex (RLPFC) activation ramped over sequence position and reset at the initiation of each new sequence. To establish the necessity and function of RLPFC in this task, participants performed the sequential task while undergoing transcranial magnetic stimulation (TMS) of the RLPFC versus two prefrontal control regions. Across two independent experiments, only RLPFC stimulation increasingly disrupted task performance as each sequence progressed. These data establish RLPFC as necessary for uncertainty resolution during sequence-level control.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.